摘要
研究了萘基薁并[2,1-d]嘧啶-4-胺类衍生物的合成方法.以托酚酮、萘乙酸乙酯、N,N-二甲基甲酰胺二甲缩醛(DMF-DMA)及芳香胺为原料,依次经过氯代、缩合、环加成、环化反应得到目标产物.该反应操作简单、条件温和、收率良好.产物的结构经1H NMR,IR及元素分析等得以证实.
In this paper,a synthetic method for naphthylazuleno[2,1-d]pyrimidin-4-amines was reported,which began from cheap tropolone,ethyl naphthaleneacetate,malononitrile N,N-dimethylformamide dimethyl acetal(DMF-DMA) and anilines,followed by chlorination,condensation,cyclization and then Dimroth rearrangement reaction,to give naphthylazuleno[2,1-d]pyrimidin-4-amines in moderate yields.The structures of synthesized compounds were determined by 1H NMR,IR spectra and elemental analysis.This method provides several advantages such as good yield and simple work-up procedure.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第8期1547-1551,共5页
Chinese Journal of Organic Chemistry
基金
辽宁省科技厅(No.2011220022)资助项目~~