血瘀证患者红细胞变形性及体外血栓研究

Study of Erythrocyte Deformability and Extracorporeal Thrombosis in Patients with Blood Stasis Syndrome

作者观测了127例肺心病、47例肾小球肾炎及17例冠心病三组血瘀证患者的红细胞变形指数(DI)和体外形成血栓的长度(L)、重量(W)、形成血栓的时间以及血液对管壁的粘附性。结果:三组血瘀证患者 DI 显著低于正常人,L 长于正常人,血液对管壁的粘附性比正常人大,但形成血栓的时间长于正常人,按病情分组研究表明,DI 的降低和 L增长的程度,与呼吸衰竭、酸碱平衡紊乱以及肾功能衰竭之是否发生有密切关系。

The patients were divided into 3 groups:127 cases of cor pulmonale,47 cases of glomerulone- phritis and 17 cases of coronary heart disease.Erythrocyte deformability indices(DI)and changes during extracorporeal thrombosis were investigated in all the 3 groups,in comparison with a group of 80 normal healthy individuals.The result showed that all the patients had notably lower DI (respectively 1.21±0.99,0.73±0.93),and 0.84±0.81 for the groups in the given order),longer length of extracorporeal thrombi(Lin mm,respectively 45.94±38.78,62.88±43.65 and 59.74±40.99)and larger top inclination angle of blood plane in silicon-lined ring tube(respectively 15.66°±6.09°,13.21°±9.33° and 12.65°±8.02°)than individuals over 40 in the comparison group.In the group of cases of cor pulmonale,patients with abnormal pH and respiratory failure had apparent greater L than those with pH compensation and without respiratory failure;diminished DI were also observed in associa- tion with pH abnormality.In the group of nephritis,patients with renal failure and chronic nephritis showed evidently lower DI than those without renal failure but acute nephritis;increased L were also noted in association with renal failure. In addition,a similar comparison was done between individuals over 40 and individuals at or younger than the age of 40.It was found that people over 40 tended to have diminished DI,increased L and Wt of extracorporeal thrombi,and augmented initial inclination angle of blood plane though not as notably as what was observed in the 3 groups of victims of blood stasis. The study contributes to revelation of mechanisms of microcirculation stagnation and microth- rombosis in patients suffering from diseases associated with blood stasis,thus providing valuable experimental evidence for microscopic analysis and differentiation,treatment and prevention of these diseases.This may also contribute to standardization and modernization of TCM classified treatment and type-treatment.Reasonable selection of drugs for medication and objective evaluation of curative effect in treatment of diseases associated with blood stasis syndrome can also provide some theoretical basis in the study.