系数倍率法测定免洗手消毒液中醋酸氯己定的含量

Content Determination of Chlorhexidine Acetate in Wash-free Antiseptic Lotion by Coefficient Multiplying Ratio Spectrophotometry

目的:测定免洗手消毒液中醋酸氯己定的含量。方法:采用系数倍率法,样品不经分离直接测定免洗手消毒液中醋酸氯己定的含量,测定波长为260、280nm。结果:醋酸氯己定检测浓度线性范围为8～12μg·mL-1(r=0.9999),平均回收率为100.66%(RSD=0.21%)。结论:本方法操作简便快速、结果准确,可用于该制剂的质量控制。

OBJECTIVE：To determine the content of chlorhexidine acetate in Wash-free antiseptic lotion.METHODS：The content of chlorhexidine acetate was directly determined at 260 nm and 280 nm by coefficient multiplying ratio spectrophotometry without preliminary separation.RESULTS：The linear range of chlorhexidine acetate was 8～12 μg·mL-1（r=0.999 9） with an recovery of 100.66%（RSD=0.21%）.CONCLUSION：The method is proved to be simple,rapid,accurate and applicable for the quality control of wash-free antiseptic lotion.