胺碘酮对冠心病心律失常心率变异性的影响

Influnce of amiodarone on coronary heart arrhythmia heart rate variability

目的观察胺碘酮对冠心病的临床治疗作用,分析该药对心律失常心率变异性的影响。方法收取2009年5月至2010年10月本院治疗的80例冠心病心率失常患者,按照随机原则分为治疗组(40例)和对照组(40例),对照组采用常规扩张冠状动脉和抗心律失常药物,而实验组则每周递减给予胺碘酮治疗。比较两组患者的治疗有效率及相关指标,探讨胺碘酮治疗冠心病心律失常的疗效。结果治疗组的治疗有效率为80%,高于对照组的65%,两组相比具有明显统计学差异(P<0.01)。两组患者在治疗过程中未发生心功能减低、肝功能异常、间质性肺炎、甲状腺功能异常及神经、眼角膜等不良反应。结论胺碘酮对冠心病心律失常的患者疗效明显,价格低廉,用药途径方便、安全,值得临床推广和应用。

Objective To observe the effect of amiodarone on clinical treatment of coronary heart disease,analysis of the drug on arrhythmia heart rate variability.Methods From May 2009 to October 2010 our hospital 80 patients with coronary heart arrhythmia patients were randomly divided into treatment group（40 cases） and control group（40 cases）,the expansion of the control group with conventional coronary artery and anti-arrhythmic drugs,while the experimental group was given amiodarone weekly decline.The two groups were compared the efficiency of treatment and related indicators of the efficacy of amiodarone in the treatment of coronary heart disease arrhythmias.Results The treatment rate was 80%,higher than 65%,respectively,compared with a statistically significant difference（P0.01）.Two groups of patients did not occur during treatment reduced heart function,liver function abnormalities,interstitial pneumonia,thyroid dysfunction and nerve,cornea and other adverse reactions.Conclusions Amiodarone in patients with coronary heart arrhythmia efficacy,low cost,convenient route of administration,security,it is worth promoting and applications.