帕瑞昔布钠对全髋关节置换术后患者自控镇痛的影响

Effects of Parecoxib sodium on patient-controlled intravenous analgesia sufentanil consumption after total hip replacement surgery

目的观察帕瑞昔布钠对全髋关节置换术后患者静脉自控镇痛效果的影响。方法随机选取全麻下行全髋关节置换术患者50例,麻醉诱导时分别静脉注射生理盐水(C组)或帕瑞昔布钠40㎎(P组)各25例,术后12h相同剂量重复给药。观察术后24h和48h的PCIA舒芬太尼用量,并且记录患者的疼痛评分及不良反应。结果 P组术后PCIA舒芬太尼24h和48h用量显著低于C组,并且24h和48h的PCIA有效按压次数也低于C组(P<0.05),术后6、24和48h的疼痛强度视觉模拟(visual aualogne scale,VAS)评分显著低于C组(P<0.05),而不良反应的发生率两组间无统计学意义(P>0.05)。结论帕瑞昔布钠可使全髋关节置换患者术后PCIA舒芬太尼用量减少,且镇痛效果优于对照组。

Objective To observe the impact of Parecoxib sodium on PCIA effect after total hip replacement patients surgery.Methods Totally 50 patients were randomized to parecoxib or placebos group.The PCIA sufentanil consumption was recorded 24h and 48h post-operation and VAS scores were also recorded.Results The sufentanil consumption and the PCIA pressing times at 24h and 48h after operation in parecoxib group was significantly lower than placebo group（P0.05）.The VAS scores in two groups at 6h,24h and 48h were statistically significant different（P0.05）and adverse reaction reduced.Conclusions The application of Parecoxib sodium at induction and 12h after operation can reduce PCIA sufentanil consumption significantly after surgery.