摘要
本实验结果表明:体外实验,散结片对肝癌细胞的赤染率可达86～92%。体内实验,散结片灌胃12.5g/kg·日·连用10日,对肝癌实体瘤平均抑制率为84%,对肝癌腹水癌平均使寿命延长率提高为78%。结散片的 LD_(50)为25g/kg。说明散结片对肝癌细胞体内外均有显著杀伤作用。病理学及超微结构观察表明:散结片对肝癌细胞具有强大的杀伤破坏作用,直接作用于肝癌细胞膜系结构,使细胞膜溶解破碎,粗面内质网扩张,线粒体肿胀,空泡化,使肝癌细胞整体崩解碎裂,是散结片抗肿瘤的主要药理作用。
In the present paper,the authors applied Sanjie pellet in the anti-cancer study on the animals. The results indicated that in the extracorporeal experiment,stomach perfusion with Sanjie pellet 12.5g/kg daily for 10 successive days,the inhibitory rate for the substantive liver cancer was 84%. For ascites liver carcinoma,it could raise the average rate of prolonging life span to 76%.Lethal dose(LD_(50))was 25 g/kg.The pathological observations indicated that Sanjie pellet acted directly on the cell membrance and organelle of the liver cancer cells and causing lysis and clasis of the cell membrance,dilation of rough surface endopliamic reticulum,the swelling of mitochondria and disintegration and clasis of the liver cancer cells body.The authors concluded that these were the main pharmacological efficacies of Sanjie pellet.
