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高血压患者血压晨峰与左心室重构的关系

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摘要 目的探讨高血压病患者血压晨峰(morning blood pressure surge,MBPS)与左心室重构的关系。方法对80例高血压患者资料进行回顾性分析,依据24h动态血压(ambulatory blood pressure monitoring,ABPM),将MBPS值≥35mmHg列入MBPS组(32例),MBPS值<35mmHg列入非MBPS(48例),计算患者的高血压病程、身高体质指数(BMI),常规检查总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG),通过心电图测量患者左心室电压,通过心脏超声计算左心室质量指数(LVMI),比较分析两组的MBPS值,分析左心室肥厚(left ventricular hypertrophy,LVH)的危险因素,分析MBPS与LVH的关系及危险性。结果两组患者BMI、TC、TG、HDL-C、LDL-C和FPG差异均无统计学意义(P>0.05)。MBPS组高血压病程为(22.69±4.32)年,非MBPS组为(17.42±4.55)年,差异有统计学意义(P<0.01)。MBPS组左心室电压为(5.03±0.46)mV,非MBPS组为(4.76±0.53)mV,差异有统计学意义(P<0.05);MBPS组24h平均收缩压、24h平均舒张压、24h平均血压分别为(139.66±3.09)、(76.86±4.15)、(108.25±3.17)mmHg,非MBPS组分别为(138.08±2.07)、(75.02±4.34)、(107.42±3.19)mmHg,MBPS组24h平均收缩压与24h平均血压高于非MBPS组,差异有统计学意义(P<0.05);MBPS组LVMI为(123.44±3.35)g/m2,非MBPS组为(121.60±3.27)g/m2,差异有统计学意义(P<0.05);MBPS组MBPS值为(37.44±1.66)mmHg,非MBPS组为(24.67±4.11)mmHg,差异有统计学意义(P<0.01)。MBPS组LVH的发生率(56.25%)高于非MBPS组(29.常7%),差异有统计学意义(P<0.01),MBPS是LVH的独立危险因素,有MBPS比非MBPS者风险高1.10倍。结论 MBPS与左心室重构的发生密切相关,高血压患者有MBPS者更易发生左心室重构。
出处 《中国慢性病预防与控制》 CAS 2012年第4期457-459,共3页 Chinese Journal of Prevention and Control of Chronic Diseases
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参考文献12

  • 1Katio K, Picketing TG, Umeda Y, et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in eldeHy hypeensives: a prospective study [J]. Circulation, 2003, 107 (10): 1401-1406.
  • 2郑琦,吴可贵,晋学庆.清晨高血压对心血管事件的影响[J].高血压杂志,2004,12(5):387-389. 被引量:89
  • 3Gossse P, Lasserre R, minifie C, et al. Blood pressure surge on rising [J]. Hypertension, 2004, 22(6) : 1113-1118.
  • 4Kario K. Morning surge in blood pressure and cardiovasaeular risk: evidence and persepctives [J]. Hypertension, 2010, 56(5): 765-773.
  • 5Metoki H, Ohkubo T, Kikuya M, et al. Prognostic significance for stroke of a moring pressor surge and a nocturnal blood pressure decline: the Ohasama study [J]. Hypertension, 2006, 47(2): 149-154.
  • 6Kaneda R, Kario K, Hoshide S, et al. Morning blood pressure hyper- rectivity is an independent predictor for hypertensive cardiac hypertrophy in a community-dwelling population [ J ]. Am J Hypertens, 2005, 18(12Pt 1): 1528-1533.
  • 7Zakopoulos NA, Tsivoulis G, Barlas G, et al. Time rate of blood pressure variation is associated with increased common carotid artery intima-media thickness [ J ]. Hypertension, 2005, 45 (4) : 505-512.
  • 8中国高血压防治指南2010[J].中华心血管病杂志,2011,39(7):579-616. 被引量:4513
  • 9Weber MA, Fodera SM. Circadian variations in cardiovascular disease chronotherapcntic approaches to the management of hypertension [J]. Rev Cardiovasc Med, 2004, 5(3) : 148-155.
  • 10Kario K. Proposal of RAS-diuretic vs RAS-calcium antagonist strategies in high-risk hypertension: insight from the 24-hour ambulatory blood pressure profile and central pressure[J]. J Am Soc Hypertens, 2010, 4 (5): 215-218.

二级参考文献13

  • 1White WB. Cardiovascular risk and therapeutic intervention for the early morning surge in blood pressure and heart rate[J],Blood Press Monit,2001,6:63-72.
  • 2Kario K, Pickering TG, Umeda Y, et al. Morning surge in blood pressure as a predictor of silent and clinical cerebrovascular disease in elderly hypertensives: a prospective study[J].Circulation,2003,18,107:1401-1406.
  • 3Oshchepkova EV, Lazareva NV, Filatova LV, et al. Morning rise of systolic blood pressure (by 24-hour ambulatory monitoring) and platelet aggregability in essential hypertension patients[J].Ter Arkh,2000,72:47-51.
  • 4Kawano Y, Tochikubo O, Minamisawa K, et al. Circadian variation of haemodynamics in patients with essential hypertension: comparison between early morning and evening[J].J Hypertens,1994,12:1405-1412.
  • 5Christoph Dodt, Ulrike Breckling, Inge Derad, et al. Plasma epinephrine and norepinephrine concentrations of health humans associated with nighttime sleep and morning arousal[J].Hypertension,1997,30:71-76.
  • 6Stern N, Sowers JR, McGinty D, et al. Circadian rhythm of plasma renin activity in older normal and essential hypertensive men: relation with inactive renin, aldosterone, cortisol and REM sleep[J].J Hypertens,1986,4:543-550.
  • 7Leary, Andrew C, Struthers, et al. The morning surge in blood pressure and heart rate is dependent on levels of physical activity after waking[J].J Hypertens,2002,20:865-870.
  • 8Shimada K, Kario K, Umeda Y, et al. Early morning surge in blood pressure[J].Blood Press Monit,2001,6:349-353.
  • 9Tofler GH, Brezinski D,Schafer CA, et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death[J].N Engl J Med,1987,316:1514-1518.
  • 10Marfella R, Gualdiero P, Siniscalchi M, et al. Morning blood pressure peak, QT intervals, and sympathetic activity in hypertensive patients[J].Hypertension,2003,41:237-243.

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