高压氧联合硝酸甘油治疗妊娠期高血压疾病合并胎儿宫内发育迟缓

Hyperbaric oxygen combined with nitroglycerin injection in the treatment of gestational hyperten- sion complicated with intrauterine growth retardation

目的观察高压氧联合硝酸甘油治疗妊娠期高血压疾病合并胎儿宫内发育迟缓（IUGR）的临床疗效。方法将60例IUGR患儿随机分为试验组及对照组，每组各30例。试验组给予硝酸甘油加高压氧治疗，对照组给予硝酸甘油治疗。全部孕妇均定期行超声检查及脐血流波形测定。结果高压氧联合硝酸甘油综合治疗后试验组总有效率为96．7％，显著高于对照组的83．3％（P〈0．05）。试验组脐动脉阻力指数值较对照组明显下降（P〈0．05）。结论高压氧联合硝酸甘油治疗妊娠期高血压疾病，能显著改善IUGR患者的血流动力学，并可获得显著临床疗效。

Objective To observe the clinical effect of hyperbaric oxygen combined with nitro- glycerin injection on intrauterine growth retardation （IUGR）. Methods Sixty IUGR infants were ran- domly divided into two groups： treatment group and control group, with 30 cases in each group. The in- fants in treatment group were treated with hyperbaric oxygen （HBO） combined with nitroglycerin injec- tion, and the infants in control group were treated with nitroglycerin injection only. All pregnant women underwent regular ultrasound examination and umbilical blood flow waveform measurement. Results The total effective rate was 96.7% after hyperbaric oxygen combined with nitroglycerin injection treat- ment,which was significantly higher than that of the control group（83.3% ） , P 〈 0.05. The umbilical artery RI value decreased significantly in treatment group than that in the control group （P 〈 0. 05 ）. Conclusions Hyperbaric oxygen combined with nitroglycerin injection in the treatment of hypertensive disorders in pregnancy can obviously improve the blood theology in patients with IUGR significantly and obtain significant clinical effect .