摘要
目的:分析紫杉醇的不良反应。方法:对本院2010年1月-2011年6月60例使用紫杉醇发生不良反应的患者资料进行回顾性分析。结果:紫杉醇的主要不良反应有恶心呕吐、过敏反应、骨髓抑制、胃肠道反应、关节肌肉痛、心脏毒性等,经治疗后治愈29例,好转28例,肾功能损伤1例,永久性脱发2例。结论:紫杉醇应用于临床应多询问患者临床反应,密切观察化疗期间的体征变化,权衡利弊或提早预防,对症处理胃肠道反应、关节酸痛、周围神经炎、骨髓抑制等不良反应,以保证患者安全有效用药。
Objective：To analyze the side-effects of paclitaxel injection.Method： 60 patients who underwent the side-effects of paclitaxel injection from January 2010 - June 2011 were analyzed retrospectively.Result：The main side-effects of paclitaxel injection including nausea and vomiting, allergic reactions, bone marrow suppression, gastrointestinal tract, joint and muscle pain and cardiac toxicity, 60 patients were cured 29 cases, 28 patients were improved, 1 patient happened renal injury, 2 patients happened a permanent hair loss.Conclusion：When Paclitaxel injection was used in clinic should ask patients about clinical response, closely observed during chemotherapy signs of change, Balance advantages and disadvantages or make early prevention of symptomatic treatment of gastrointestinal reactions, which is joint pain, peripheral neuropathy, bone marrow suppression and other side-effect, in order to ensure the safe, effective drug-use in patients.
出处
《中国医学创新》
CAS
2012年第23期146-147,共2页
Medical Innovation of China
关键词
紫杉醇
药物不良反应
治疗
预防
Paclitaxel
Adverse drug reactions
Treatment
Prevention
