聚L-乳酸修饰的聚丙烯疝补片的研制及动物实验研究

Modified polypropylene mesh by grafting polymerization of L-lactic acid and its application on animal experiment

目的将聚L-乳酸修饰的聚丙烯补片应用于动物实验,进一步验证补片的防粘连效果。方法聚L-乳酸修饰的聚丙烯补片置入腹腔并覆盖腹腔缺损,同时与聚丙烯补片为对照组,通过腹腔内粘连面积、粘连程度、组织病理学改变等检查了解补片粘连情况。结果单纯聚丙烯组术后死亡率高,剖腹探查发现补片表面与腹腔脏器发生直接粘连,粘连面积广泛,粘连程度重。聚L-乳酸修饰的聚丙烯组补片表面亦有粘连,主要集中在补片边缘粘连面积、程度较轻。结论聚L-乳酸修饰的聚丙烯平片是可行的,动物实验表明聚L-乳酸修饰的聚丙烯补片可以减少动物的腹腔内粘连。

Objective Polypropylene （PP） covered with pely L-lactic acid （PLLA） via a facile approach was modified and then the PLLA-PP mesh on animal experiment was applied to evaluate its anti-adhe- sion and biocompatibility. Methods Poly L-lactic acidodified polypropylene patch was placed in the abdominal cavity and covered the abdominal defect with polypropylene patch for the control group. Intra-abdominal adhesion area, degree of adhesion, and histopathology changes were used to check patch adhesion. Results Postoperative mortadity in pure polypropylene group was high. The direct adhesion of the patch surface and the abdominal viscera was explored by laparotomy with wide adhesion area of severe adhesions. The patch surface had adhesion as well in the poly L-lactic acid-modified polypropylene group, mainly in the area of the patch edge of minor adhesion. Conclusions Poly L-lactic acid-modified polypropylene plain film is feasible, animal experiments showed that poly L-lactic acid-modified polypropylene patch can reduce the abdominal cavity adhesions.