HBV-LP检测在慢性乙型肝炎患者抗病毒治疗中的应用

Value of HBV-LP in patients with chronic hepatitis B receiving antivirus treatment

目的探讨乙型肝炎病毒外膜大蛋白(HBV-LP)检测在慢性乙型肝炎患者抗病毒治疗中的应用价值。方法对抗病毒治疗有效并-70℃冻存的56例慢性乙型肝炎患者系列血清做HBV-LP、雅培(ABBOTT)乙型肝炎两对半和HBVDNA定量检测。结果在56例抗病毒治疗有效病例中,HBeAg阳性组的HBV-LP的A值为1.11±0.40,阴性组的A值0.5616±0.21,差异有统计学意义。56例干扰素治疗有效病例的HBV-LP和HBVDNA随用药时间的同时下降,两者有很好的相关性,P=0.0232,r2=0.8603。结论 HBV-LP可作为判断慢性乙型肝炎抗病毒较为可靠的指标,尤其在HBeAg阴性的乙型肝炎患者进行抗病毒治疗时更具有重大意义。

Objective To investigate the clinical value of hepatitis B virus-large surface protein（HBV-LP） in patients with chronic hepatitis B（CHB） receiving antivirus treatment.Methods Serum samples,frozen at-70 ℃ and detected from 56 cases of patients with CHB receiving valid antivirus treatment,were detected for HBV-LP,HBV surface antigen（HBsAg）,HBV surface antibody（HBsAb）,HBV e antigen（HBeAg）,HBV e antibody（HBeAb）,HBV core antibody（HBcAb）,and HBV DNA.Results The mean of A value of HBV-LP in HBeAg positive group was higher than HBeAg negative group（1.11±0.40 vs 0.561 6±0.21,P〈0.05）.Level of HBV-LP and HBV DNA decreased after antivirus treatment.Level of HBV-LP was positively correlated with HBV DNA（r2=0.860 3,P〈0.05）.Conclusion HBV-LP might be useful for evaluating the efficacy of antivirus treatment for CHB,especially in patients negative with HBeAg.