糖化血红蛋白、胱抑素C、尿微量清蛋白联合检测在2型糖尿病中诊治的应用

Application of combined detection of HbA1c,CysC and mAlb for the diagnosis and treatment of type 2 diabetes melitus

目的探讨糖化血红蛋白(HbA1c)、胱抑素C(CysC)、尿微量清蛋白(mAlb)联合检测在2型糖尿病诊治中的应用。方法共纳入确诊2型糖尿病56例,分别测定二甲双胍缓释片治疗前后HbA1c、CysC、mAlb和肌酐(Crea)水平,监测治疗效果。结果整个疗程中,将治疗前测定的HbA1c、CysC、mAlb和Crea水平作为基线水平,组内重复测量表明,HbA1c、CysC、mAlb水平在整个治疗过程中有明显下降趋势(P<0.05);不良反应率差异无统计学意义(P>0.05)。结论 HbA1c、CysC、mAlb是反映糖尿病早期肾损害的良好指标。

Objective To explore the application of combined detection of glycosylated hemoglobin A1（HbA1c）,Cystatin C（CysC） and urine micro-albumin（mAlb） for the diagnosis and treatment of type 2 diabetes mellitus（T2DM）.Methods 56 patients with definite diagnosis of T2DM were enrolled and detected for HbA1c,CysC,mAlb and creatinine（Crea） before and after treatment of melbine to monitor the efficacy of treatment.Results In the whole course of treatment,there was decreasing tendency of levels of HbA1c,CysC and mAlb,taking the results detected before treatment as baseline（P〈0.05）,and incidence of adverse effect was not significant different（P〉0.05）.Conclusion HbA1c,CysC and mAlb might be good indexes to reflect early renal damage cased by diabetes.