期刊文献+

单纯性肥胖成人血清高敏C反应蛋白、血脂水平与胰岛素抵抗的相关性研究 被引量:10

Relationship between insulin resistance and serum high sensitivity C-reactive protein,blood lipids level in adult with simple obesity
下载PDF
导出
摘要 目的探讨单纯性肥胖成人血清高敏C反应蛋白(hs-CRP)、血脂水平与胰岛素抵抗(IR)的关系。方法选择单纯性肥胖成人99例[按体质量指数(BMI)分为i度肥胖组46例,ii度肥胖组38例,iii度肥胖组15例],单纯性超重成人56例及健康成人80例。测定所有入选对象的身高、体质量、腰围、臀围、空腹血糖(FBG)、空腹胰岛素(FIN)、血脂、hs-CRP水平,并计算胰岛素抵抗指数(HOMA-IR)、BMI及腰臀比(WHR)。结果 hs-CRP、HOMA-IR、FBG、FIN、TG、TC、LDL-C、脂肪肝发生率随着BMI的升高呈逐渐升高趋势,HDL-C则呈现逐渐降低趋势。血清hs-CRP与BMI、WHR、FIN、HOMA-IR、TG呈显著正相关(P<0.05~P<0.01),与HDL-C呈显著负相关(P<0.01),多元逐步回归分析提示,BMI、HOMA-IR、HDL-C是影响hs-CRP的独立危险因素。结论单纯性肥胖成人存在IR,炎性因子hs-CRP的过量表达参与并加重单纯性肥胖成人IR、血脂紊乱的发生和发展。 Objective To explore the relationship between insulin resistance(IR) and serum high sensitivity C-reactive protein(hs-CRP),blood lipids level in adults with simple obesity.Methods Ninety nine adults with simple obesity were divided into 3 groups according to body mass index(BMI),including forty six cases in i degree obesity group,thirty eight cases in ii degree obesity group and fifteen in iii degree obesity group,and fifty six adults with simple overweight and eighty healthy adults were also enrolled.All selected cases were measured for height,body weight,waistline,hip circumference,fasting blood glucose(FBG),fasting insulin(FIN),blood lipids and hs-CRP.IR index(HOMA-IR),BMI and waist-hip-ratio(WHR) were calculated.Results When BMI increased,levels of hs-CRP,HOMA-IR,FBG,FIN,triglyceride(TG),cholesterol(TC),low density lipoprotein-cholesterol(LDL-C) and incidence of fatty liver were gradually increased.However,high density lipoprotein-cholesterol(HDL-C) was gradually degraded.Hs-CRP was significantly positively correlated with BMI,WHR,FIN,HOMA-IR and TG(P〈0.05 or P〈0.01),and significantly negatively correlated with HDL-C(P〈0.01).Multiple stepwise regression analysis indicated that BMI,HOMA-IR and HDL-C were independent risk factors influencing hs-CRP.Conclusion The overexpression of inflammatory factor hs-CRP might participate and aggravate the occurrence and development of IR and lipid disorders in adults with simple obesity.
作者 李国栋 郑青
出处 《国际检验医学杂志》 CAS 2012年第13期1587-1589,共3页 International Journal of Laboratory Medicine
关键词 单纯性肥胖 C反应蛋白质 血脂 胰岛素抵抗 simple obesity; C-reactive protein; blood lipids; insulin resistance
  • 相关文献

参考文献11

  • 1Wellen KE, Hotamishigil GS. Inflammation, stress, and diabetes[J].J Clin Invest,2005,115(5):1111-1119.
  • 2Kosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis[J]. Nature, 2006,444 (7121):847-853.
  • 3Tryhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat[J]. Acta Physiol Scand, 2005, 184 (4): 285- 293.
  • 4Sugita H, Kaneki M, Sugita M, et al. Burn injury impairs insulin- stimulated Akt/PKB activation in skeletal muscle[J]. Am J Physi- ol Endoerinol Metab, 2005,288 (3) : E585-E591.
  • 5Dugo L,Collin M,Thiemermann C. Glycogen synthase kinase 3 as a target for the therapy of shock and inflammation[J]. Shock, 2007,27(2) :113-123.
  • 6Hotamishigil GS. Inflammation and metabolic disorders[J]. Na- ture,2006,441 (7121) : 860-867.
  • 7Kovacs A,Green F,Hansson LO,et al. A novel common sigle nu- cleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reac- tive protein[J]. Atheroselerosis,2005,178(1) : 193-198.
  • 8Retnakaran R, Hanley AJ, Connelly PW, et al. Elevated C-reactive protein in native Canadian childred:an ominous early complication of childhood obesity[J]. Diabetes Obes Metab, 2006,8 (5) : 483- 491.
  • 9Florez H,Castllo FS,Mendez A,et al. C-reactive protein is elevat- ed in obese patients with the metabolic syndrone[J]. Diabetes Res Clin Pract,2006,71(1):92-100.
  • 10Guven A, Cetnkaya A, Aral M, et al. High-sensitivity C-reactive protein in patients with metabolic syndrone[J]. Angiology, 2006, 57(3) :295-302.

同被引文献111

引证文献10

二级引证文献49

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部