血清CK18及CA72-4水平在胃癌诊治中的临床价值

Clinical significance of serum CK18 and CA72-4 in gastric cancer

目的探讨血清细胞角蛋白18(CK18)和糖类抗原72-4(CA72-4)水平在胃癌患者临床诊治中的价值。方法分别采用酶联免疫吸附(ELISA)法和电化学发光法检测89例胃癌患者手术前、后血清CK18和CA72-4水平,并与胃良性病变患者35例及健康对照组37例进行对比分析。结果血清CK18和CA72-4水平胃癌组高于胃良性疾病组和健康对照组,差异有统计学意义(P<0.01);胃癌手术前组高于手术后组,差异有统计学意义(P<0.01);有淋巴结转移组高于无淋巴结转移组,差异有统计学意义(P<0.01)。在胃癌组中行根治性手术患者术后血清CK18和CA72-4水平低于姑息性切除者,差异有统计学意义(P<0.01)。结论血清CK18和CA72-4水平测定对良、恶性胃癌的诊断具有重要意义;监测CK18和CA72-4的动态变化,对胃癌患者的疗效观察、预后评估有重要的价值。

Objective To explore the clinical significance of serum CK18 and CA72-4 for clinical diagnosis and treatment of gastric cancer.Methods Electrochemiluminescene analyzer was used to detect the content of serum CK18 and CA72-4 in 89 patients with stomach cancer and 47 patients with benign stomach diseases as control group.Results Levels of CK18 and CA72-4 in cancer group were higher than those in control group（P〈0.01）,and those in cancer group before surgery were higher than after surgery（P〈0.01）.Conclusion Detection of CK18 and CA72-4 might be with important significance for the differential diagnosis of benign and malignant stomach diseases.Dynamic monitoring of CK18 and CA72-4 might be helpful for evaluation of treatment efficiency and prognosis for gastric cancer.