血清CEA、NSE、CYFR21-1水平检测在肺癌诊断和鉴别诊断的应用价值

Significance of CEA,NSE and CYFR21-1 levels in serum for the diagnosis and differential diagnosis of lung cancer

目的探讨血清CEA、NSE、CYFR21-1水平在肺癌诊断和鉴别诊断的应用价值。方法采用电化学发光法,检测102例肺癌患者、52例肺良性病变患者和30例健康体检者血清CEA、NSE、CYFR21-1水平。结果血清CEA、NSE、CYFR21-1水平与病理类型有关,CEA水平升高以肺腺癌为主,敏感性为53.49%;CYFR21-1水平升高以肺鳞癌为主,敏感性为62.85%;NSE升高以小细胞肺癌为主,敏感性为77.27%。结论 CEA联合NSE、CYFR21-1检测可提高对肺腺癌的敏感性,CYFR21-1单项或联合NSE检测可用于肺鳞癌的诊断和鉴别诊断,单纯NSE检测即对小细胞肺癌的诊断和鉴别诊断具有重要意义。

Objective To explore the significance of the detection of carcino-embryonic antigen（CEA）,neurone specific enolase（NSE） and Cytokerantin-19-fragment（CYFR21-1） for the diagnosis and differential diagnosis of lung cancer.Methods 102 patients with lung cancer,52 patients with benign lung diseases and 30 healthy subjects were enrolled and detected for the serum levels of CEA,NSE and CYFR21-1 by electrochemiluminescence.Results Serum levels of CEA,NSE and CYFR21-1 serum were associated with the pathological type.High level of CEA was mainly in adenocarcinoma of lung,with sensitivity of 53.49%.Increasing of CYFR21-1 level was mainly in squamous cell carcinoma of lung,with sensitivity of 62.85%,and that of NSE levels was mainly in small cell lung cancer,with sensitivity of 77.27%.Conclusion Detection of CEA,combined with NSE and CYFR21-1 could improve the detection sensitivity of lung adenocarcinoma.Detection of CYFR21-1,alone or combined with NSE,could be used for the diagnosis and differential diagnosis of squamous cell carcinoma of lung.Single detection of NSE could be with great significance for the diagnosis and differential diagnosis of small cell lung cancer.