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Th22细胞在炎症免疫性疾病中作用的研究进展 被引量：4

Research progress of Th22 cells in inflammatory immunity diseases
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摘要 Th22细胞是最近发现的CD4+T细胞功能亚群,表达CCR6、CCR4和CCR10,且分泌IL-22和TNF-α,不分泌IFN-γ、IL-4、IL-17,是独立于Th1、Th2和Th17的细胞亚群。Th22细胞主要参与皮肤的自稳调节和病理状态,可以调控皮肤的固有免疫反应、防御功能及表皮损伤后的修复功能,在炎症性皮肤病的病理生理机制中发挥重要作用。此外,Th22细胞也参与了炎症性肠病、类风湿关节炎、肝炎、试验性自身免疫性心肌炎等炎症免疫性疾病的病理过程。本文对Th22细胞其细胞因子IL-22在炎症免疫性疾病中作用的研究进展做一综述。 Th22 cells are recently described as one of the inflammatory CD4＋ T cells that express CCR6, CCR4, and CCR10. Th22 cells, separated clearly from those of Thl, Th2, and Thl7 cells, can produce IL-22, TNF- α, but do not express IL-17A, IL-4 or IFN-γ. Th22 cells may present within the epidermal layer in inflammatory skin diseases, which related to orchestrating innate immune responses, regulating keratinocyte defense mechanisms and enhancing epidermal wound healing. Furthermore, Th22 plays an important role in the pathogenesis of inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, hepatitis, and experimental autoimmune encephalomyelitis. This article reviews the role of Th22 cells and its cytokine IL-22 in inflammatory immunity diseases.
作者 吴华勋 魏伟
机构地区 安徽医科大学临床药理研究所抗炎免疫药理学教育部重点实验室
出处 《免疫学杂志》 CAS CSCD 北大核心 2012年第9期816-819,共4页 Immunological Journal
基金 国家自然科学基金(30973543 81173075) 安徽省研究实验基地优秀中青年科研带头人基金(200622805) 安徽高校省级自然科学研究项目(KJ2011Z181)
关键词 TH22细胞 IL-22 炎症免疫性疾病 Th22 cells IL-22 Inflammatory immunity diseases
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献21

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二级参考文献12

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共引文献4

同被引文献44

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引证文献4

二级引证文献8

免疫学杂志
2012年 第9期

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