207株肺炎克雷伯菌临床分布及耐药性分析

Clinical distribution and drug resistance analysis of 207 Klebsiella pneumoniae strains

目的分析临床分离肺炎克雷伯菌对抗菌药物的耐药性。方法对临床分离肺炎克雷伯菌用纸片扩散法(K-B)或微量稀释法对16种抗菌药物进行药物敏感试验。结果产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌59株,对头孢曲松、头孢呋辛、头孢噻肟、头孢哌酮、头孢噻吩、复方新诺明、美洛西林有很高的耐药率,分别是91.53%、91.53%、100.00%、100.00%、93.22%、72.88%和91.53%,甚至出现多重耐药菌株。结论产ESBLs肺炎克雷伯菌耐药情况非常严重,应加强医院感染监测和控制措施。

Objective To analyse the drug resistance of Klebsiella pneumoniae.Methods the disk diffusion method（KB） or micro-dilution method（MIC） was used to detect the resistance rates of Klebsiella pneumoniae clinical isolates to 16kinds of antibacterial drugs.Results There were 59strains of Klebsiella pneumoniae producing extended spectrum β-lactamase（ESBLs）,and they had high resistance rates to ceftriaxone（91.53%）,cefuroxime（91.53%）,cefotaxime（100.00%）,cefoperazone（100.00%）,cephalothin（93.22%）,co-trimoxazole（72.88%）,mezlocillin（91.53%）,respectively.There are even multi-drug-resistant strains were detected.Conclusion The drug resistance of ESBLs producing Klebsiella pneumoniae is very serious.The hospital infection surveillance and control measures should be strengthen.