摘要
目的研究组织因子途径抑制物-2（TFPI-2）在非小细胞肺癌中的表达及其临床意义。方法应用免疫组织化学SP法检测56例手术切除的肺癌石蜡标本及12例肺部良性病变的肺正常组织中的TFPI-2的蛋白表达情况。结果①TFPI-2在非小细胞肺癌中的表达阳性率为21．4％，低于正常肺组织（75．0％，P〈0．05）；②TFPI-2在鳞癌中的蛋白表达阳性率低于腺癌（9．4％VS37．5％，P〈0．05），Ⅰ＋Ⅱ期非小细胞肺癌组织TFPI-2表达阳性率高于Ⅲ＋Ⅳ期非小细胞肺癌组织（31．3％vs8．3％，P〈0．05），而组织分化程度对TFPL2表达阳性率的影响无统计学差异；③吸烟指数≥400的肺癌患者TFPI-2表达阳性率低于吸烟指数〈400（包括不吸烟者）的患者（8．6％VS42．9％，P〈O．05）；④56例非小细胞肺癌组织中，TFPI-2表达阳性患者的肿瘤最大直径均小于5cm，在肿瘤最大直径大于5cm的患者肺癌组织中，TFPb2基本不表达。结论TFPI-2的低表达可能在非小细胞肺癌的发生、发展过程中起重要作用，TFPI-2的表达与非小细胞肺癌的病理类型、临床分期、吸烟指数、肿瘤直径是否小于5cm密切相关，与组织的分化程度无关。
Objective To study the proteitl expression level and clinical significance of tissue factor pathway inhibitor-2 （TFPb2） in non-small cell lung cancer. Methods The protein expression of TFPI-2 in paraffin specimens of 56 cases of non-small cell lung cancer and 12 specimens of normal lung tissues by SP immunohistochemistry was detected. Results ①The positive rate of TFPI-2 was lower in non-small cell lung cancer than that in normal lung tissues （21.4% vs 75.0%, P 〈0.05）. ②The positive rate of TFPI-2 expression was lower in squamous carcinoma tissues than that in adenocarcinoma tissues （9.4 vs 37.5%, P 〈0.05）. The positive rate of TFPI-2 was higher in stage Ⅰ＋Ⅱ than that in stage Ⅲ＋Ⅳ （31.3% vs 8.3%, P 〈0.05）. TFPI-2 expression had no obvious relationship with the differentiation grade. QThe positive rate of TFPI-2 expression was lower in patients whose smoking index ≥400 than that,400 （8.6% vs 42.9~, P 〈0.05）. ④ In the 56 cases,the max diameter of the turner was less than 5 cm in patients whose TFPI-2 expression was positive, it showed obvious difference between the max diameter more than 5 cm and less than 5cm, Conclusions The low expression of TFPI-2 may play an important role in the cancer genesis and development. TFPI-2 expression in non-small cell lung cancer has no obvious relationship with the differentiation grade. It is closely related to pathologic type, clinical stage, smoking index and max diameter.
出处
《国际呼吸杂志》
2012年第15期1121-1124,F0003,共5页
International Journal of Respiration
