survivin与非小细胞肺癌关系的研究进展

Research progress on association between survivin and non-small cell lung cancer

生存素（survivin）作为一种凋亡抑制因子，具有抑制细胞凋亡和调节细胞分裂双重功能，它通过作用于细胞凋亡途径中的酶促进细胞增殖，参与血管形成，且survivin在大多数肿瘤组织中特别是非小细胞肺癌中表达而在成人正常组织中不表达或低表达。因此无论是通过病理组织还是近几年的对于非小细胞肺癌患者外周血的检测均发现，survivin有望在在非小细胞肺癌的诊断、治疗及预后的评估等方面有广阔的临床应用前景。本文主要综述了实验和临床研究的各种证据，总结survivin与非小细胞肺癌关系的研究进展。

Survivin is an inhibitor of apoptosis. It can inhibit cell apoptosis and adjust cell division. Through the enzymes in the apoptosis pathway, it can promote cell proliferation and be involved in vascular formation. Survivin expresses in most tumor tissues especially non-small cell lung cancer and lowly expresses in normal tissues of the adult. Therefore, either by pathological tissue or peripheral blood testing in patients with non-small cell lung cancer, a series of experiments show that survivin is expected to have broad prospects of clinical application in the diagnosis, treatment, prognostic assessment of nonsmall cell lung cancer. This view summarizes the experimental and clinical evidences for the study progress on association between survivin and NSCLC.