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14-3-3蛋白在阿尔茨海默病中的作用机制

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摘要 14-3-3蛋白在大脑中是含量最高的蛋白,具有调节细胞周期进程、程序性死亡、细胞增殖和生存等基本生命过程。从14-3-3蛋白的抗凋亡作用和与tau的作用中阐述近年来国内外学者对AD的作用机制。但14-3-3蛋白靶蛋白有上百种,它在AD的发病和病理过程中的机制和综合效应有待进一步研究。
作者 孙国杰 刘若兰 杜艳军 陈邦国 王述菊 周华
机构地区 湖北中医药大学针灸骨伤学院
出处 《中华中医药学刊》 CAS 2012年第8期1706-1707,共2页 Chinese Archives of Traditional Chinese Medicine
基金 国家自然科学基金资助项目(30901925) 武汉市晨光科技计划项目(200850731347) 湖北省自然科学基金资助项目(2007ABA084)
关键词 14-3-3蛋白 阿尔茨海默病 作用机制
分类号 R222.19 [医药卫生—中医基础理论]
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参考文献17

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二级参考文献16

  • 1Braak E, Braak H, Mandelkow EM. A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads. Acta Neuropathol (Berl), 1994, 87: 554-567.
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中华中医药学刊
2012年 第8期

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