雷公藤内酯醇对RA滑膜新生血管翳中bFGF抑制机理的研究

Discussion of Inhibition Mechanisms of bFGF for Triptolide in Newborn Blood Vessel of Rheumatoid Arthritis Synovial Membrane

目的:为了解雷公藤内酯醇对类风湿性关节炎滑膜新生血管中bFGF的影响,探讨雷公藤对类风湿关节炎的治疗机理。方法:应用免疫组化技术检测bFGF在AA大鼠滑膜组织中的表达,并观察了雷公藤对其的影响。结果:雷公藤组可见少量的bFGF阳性细胞,与对照组比较差异有统计学意义(P<0.01)。结论:雷公藤内酯醇能降低滑膜组织中bFGF的表达水平,抑制血管生成,起到治疗作用。

Objective：To understand effects of bFGF on Triptolide in rheumatoid arthritis synovial organization and dis- cuss the influence of tripterygium wilfordii treatment mechanism of rheumatoid arthritis. Methods ： Use immunohistochemi-cal techniques to detect expression of bFGF in the AA rats in the organization of the synovial organization, and to observe the effects of tripterygium wilfordii. Results ： The tripterygium wilfordii group showed a few of positive bFGF cells, compared with the experimental group, it had significant difference （ P 〈 0.01 ）. Conclusion ： Triptolide can reduce the expression lev- els of bFGF in synovial organizations and inhibit angiogenesis, playing a therapeutic role.