丹参水提物对化学引起大白鼠心肌缺血的保护作用

Protective Action of Salvia miltiorrhiza Aqueous Extract on Chemically Induced Acute Myocardial Ischemia in Rats

丹参水提取物(SM-H)预防异丙肾上腺素(ISO)或氯化钡引起大白鼠急性心肌缺血和心律失常有如下的显著效应:(1)腹腔注射 SM-H,连续3～5天,或1次静脉注射,均能显著地减少动物的死亡率;(2)静脉注射 SM-H 进行氯化钡恒速灌注,显著提高导致动物心律失常而致死的氯化钡剂量;(3)腹腔注射 SM-H,显著防止或减少氯化钡静脉注射引起大白鼠的室性过早搏动、心室纤颤、心搏过缓以及死亡率;(4)腹腔注射 SM-H,能显著缩小 ISO 引起大白鼠心电图的 J-点位移。

Aqueous extract of Salvia miltiorrhiza(SM-H)can protect the acute myocardial ischemia and arrhythmia of Sprague-Dawley rats induced by isoproterenol(ISO)or BaCl_2 with the following results:(1)intraperitoneal injection(i.p.)of SM-H for 3 to 5 days or intravenously(i.v.)just once significantly reduced the death rate of the animals,(2)i.v.SM-H pretreatment significantly increased the lethal dose of BaCl_2 infusion,(3)i.p.SM-H significantly decreased premature ventricular contraction,ventricular fibrillation,bradycardia and mortality rate induced by bolus i.v.of BaCl_2, and(4)i.p.SM-H also significantly reduced ECG J-point displacement of rats induced by ISO.