脂肪激素促酰化蛋白在心血管疾病中的研究进展

Research Progress of Fat Hormone Acylation Protein in Cardiovascular Diseases

近年来研究显示促酰化蛋白(ASP)作为一种新型脂源性激素,与肥胖、血脂异常、糖尿病和心血管疾病的发生、发展密切相关。ASP信号途径及ASP调控能量代谢的机制也有了进一步的发现。ASP与胰岛素相比,可能具有更强的促进脂肪组织合成三酰甘油的能力,影响餐后脂肪酸的代谢分布,对心血管疾病的发生、发展提供新的研究思路。现就近年来ASP与心血管疾病的研究进展予以综述。

In recent years a large number of studies have shown that acylation stimulating protein （ASP）, as a new type of lipid peroxidation-derived hormone, is closely related to obesity, dyslipidemia, dia- betes and cardiovascular disease. Further discoveries were also made in ASP pathway and regulation of energy metabolism mechanism. ASP may have stronger function than insulin to promote the adipose tissue triglycer- ides synthesis, affecting the distribution of meal fatty acid metabolism. The researching of ASP also provide new ideas for cardiovascular disease genesis and development. Here is to make a review on ASP research pro-gress in recent years.