上皮细胞间质转化对大肠癌肝转移的早期预测和靶向治疗的研究进展

Research Progress of the Earty Detection and Target Therapeudic Role of Epithelial-mesenchymal Transition in Liver Metastases of Colorectal Cancer

大肠癌肝转移在全世界有着很高的发病率和病死率,研究显示大肠癌肝转移都有上皮细胞间质转化的特征,而上皮细胞间质转化过程中出现的一些分子标志物对大肠癌肝转移的早期预测和指导靶向治疗有着重要的作用。很多临床医师从事这项科研,其中一些问题已经有了答案,但是更多重要的问题仍需解决。研究者们期待在不久的将来,对上皮细胞间质转化分子标志物的研究,能更准确地预测大肠癌肝转移,并实现最佳的靶向治疗。

Liver metastases of colorectal cancer causes high morbidity and mortality worldwide. Resear- ches suggest that liver metastases of colorectal cancer is characterized by epithelial-mesenchymal transition （EMT）. During the progression of EMT,a few important markers of therapeutic targets and prognostic have been found. Many clinicians are engaged in the research, and some questions have been answered, however, many important issues remain unresolved. It＇s hoped that in the near future, we can exactly demonstrate the role of EMT in the liver metastases of colorectal cancer to forecast the metastases and determine the best tar- geted treatment.