喉癌干细胞表面标志物研究概况

Research Situation of Laryngeal Cancer Stem Cell Surface Markers

干细胞是具有自我更新和向多种细胞分化能力的一类细胞。基因突变干扰了干细胞正常的自我更新和分化,从而使其转变成为肿瘤干细胞,并进一步转变为肿瘤细胞。这提示如果能在肿瘤细胞中分离鉴定出肿瘤干细胞,对于肿瘤的治疗、转移复发的预防及预后判断等具有重要的临床意义。而肿瘤干细胞表面标志物是分离鉴定肿瘤干细胞的重要物质基础。

Stem cells is a class of cells of self-renewal and differentiation potentials into a variety of cells. Gene mutations interferes with the normal stem cells self-renewal and differentiation, making it turn into cancer stem cells, and further into tumor ceils. It suggests that separation and identification of the cancer stem cells from tumor cells is of great clinical significance for cancer treatment, metastasis and recurrence prevention and prognosis judgment etc.. And cancer stem cells surface marker is the important material basis for separation and identification of cancer stem cells.