多囊卵巢综合征与炎性因子关系的研究进展

Research Progress of Polycystic Ovarian Syndrome and Inflammatory Cytokines

多囊卵巢综合征(PCOS)是育龄妇女常见的代谢异常和生殖功能障碍疾病,临床高度异质,病因复杂。近年来研究表明PCOS可能是一种低度慢性炎症性疾病,并且慢性炎症对PCOS的远期并发症的发展有重要作用。研究发现,PCOS患者外周血中的一些炎性因子(如肿瘤坏死因子α、C反应蛋白等)水平增高,表明低度慢性炎症可能在PCOS的发展中发挥作用,这可能与PCOS的发病机制有关。

Polycystic ovarian syndrome （PCOS）is the most common endocrine metabolic disorder and dysgene- sia of women in reproductive age. It is a heterogeneous and complicated disease. Recently, studies have shown that PCOS may be a low-grade chronic inflammation disease, which is closely related with the long-term complications of PCOS. Study found that in the peripheral blood of PCOS patients some inflammatory factor（ such as tumour necrosis facter a, C-reactive protein etc）levels increased, indicating that low-grade chronic inflammation may play a role in PCOS development, which may be related to the pathogenesis of PCOS.