摘要
近年来鲍曼不动杆菌引起的医院感染和社区感染日益增多,并呈现出多重耐药甚至泛耐药趋势。其耐药机制复杂多样,主要有产生药物相关酶类、药物作用靶位改变、细菌外膜通道蛋白改变、药物主动外排及其他耐药机制。多重耐药性的产生通常由一种机制或多种机制共同作用导致。现对近年来鲍曼不动杆菌主要耐药机制的研究进展进行归纳,为指导临床治疗和研究提供参考。
In recent years, outbreaks of nosocomial and community infection caused by multi-drug-resist- ant or pan-resistant Acinetobacter baumannii strains have increased. The resistance mechanism of Acinetobact- er baumannii is complex, which include production of drug-hydrolyzing enzymes, changes of drug target, chan- ges of porin proteins, drug initiative affiux and others. The multi-drug-resistance is usually generated by one or several mechanisms. Here is to summarize the progress in resistance mechanism of Acinetobacter baumannii and provide references to clinical treatment and research.
出处
《医学综述》
2012年第15期2463-2466,共4页
Medical Recapitulate
关键词
鲍曼不动杆菌
多重耐药
耐药机制
研究进展
Acinetobacter baumannii
Multi-drug-resistant
Drug resistant mechanism
Research advances
