硼中子俘获治疗人脑胶质母细胞瘤的前景和困惑

Boron neutron capture therapy for glioblastoma of prospects and confused

硼中子俘获疗法是一种可以选择性杀伤肿瘤细胞的放射疗法,其产生的α粒子对临床治疗新诊断和复发的脑胶质母细胞瘤有较好的疗效。发达国家20世纪五六十年代就已进入临床试验,但一直受到硼携带载体和中子源发展的限制。现就其治疗脑胶质母细胞瘤的前景做一综述。

Boron neutron capture therapy（BNCT） is a selective radiotherapy of damage tumor cells,and α particle produced by which is effective to prevent glioblastoma multiform recurrence.Clinical trails of BNCT were carried out in fifties to sixties of 20 century in developed countries,but it was limited because of the development of boron carrier and neutron source.This is a review of BNCT prospect on glioblastoma multiform.