帕瑞昔布治疗腭咽成形术后疼痛42例

Analgesia Efficacy of Parecoxib for Uvulopalatopharyngoplasty Postoperative Patients

目的观察帕瑞昔布对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者腭咽成形术后的静脉镇痛效果。方法 42例行悬雍垂腭咽成形术OSAHS患者,随机分为治疗组和对照组各21例,治疗组术后拔管前静脉注射帕瑞昔布40 mg,以后40 mg·d-1静脉注射,连续3 d;对照组给予0.9%氯化钠注射液静脉注射。疼痛视觉模拟评分评价术后疼痛程度,记录术后2,12,24,48 h评分结果,监测凝血功能。结果治疗组术后2,12,24,48 h疼痛视觉模拟评分均明显低于对照组(P<0.05),帕瑞昔布对凝血功能无明显影响(P>0.05)。结论帕瑞昔布有较明显的术后镇痛效果,用于OSAHS患者术后镇痛安全有效。

Objective To investigate the analgesia efficacy of parecoxib for uvulopalatopharyngoplasty（UPPP） postoperative patients.Methods Forty-two patients of obstructive sleep apnea hypopnea syndrome（OSAHS） undergoing UPPP were randomly assigned to treatment group and control group（n=21 of each）.The treatment group patients were given a single dose of parecoxib 40 mg before extubation and 40 mg·d^-1 during following 3 days.The control group patients were given normal saline as a placebo.Visual analog scale（VAS） was used to evaluate the degree of postoperative pain and the scores at 2 h,12 h,24 h,48 h post operation and the blood coagulation were recorded.Results Parecoxib showd significantly postoperative analgesia efficacy（P〈0.05） but little impact on blood coagulation.Conclusion Parecoxib could be used safely as postoperative analgesia for OSAHS patients.