期刊文献+

同型半胱氨酸与神经管畸形发生关系的研究进展

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摘要 神经管畸形(NTDs)是由于在胚胎发育过程中,神经管闭合不全所引起的一组缺陷,包括无脑畸形、脑膨出、脊柱裂、脑脊膨出等,其发生率高,后果严重。世界范围内神经管畸形发病率为0.05%-0.2%。
机构地区 承德医学院
出处 《承德医学院学报》 2012年第3期304-306,共3页 Journal of Chengde Medical University
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参考文献19

  • 1Greene ND,Stanier P, Copp AJ.Genetics of human neural tube defects[J].Hum Mol Genet,2009, 18(R2):R113-129.
  • 2高光清,卢晓琳,白继保,白春林.妊娠神经管畸形孕妇血清叶酸与同型半胱氨酸水平分析[J].中国妇幼保健,2010,25(14):1903-1905. 被引量:17
  • 3Steegers-Theunissen RP, Smithells RW, Eskes TK.Update of new risk factors and prevention of neural-tube defects[J].Obstet Gynecol Surv,1993,48(5):287-293.
  • 4Nelen WL,Blom HJ,Thomas CM,et al.Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting form low dose folic acid supplementation in women with unexplained recurrent miscarriages[J].J Nutr,1998,128(8): 1336-1341.
  • 5Steergers-Theunissen RP, Boers GH, Trijbels FJ, et al. Matemal hyperhomocysteinemia: a risk factor for neural-tube defects[J]. Metabolism, 1994,43(12): 1475-1480.
  • 6张泽峰,朱慧萍,李竹.神经管畸形高低发区婚检妇女血清游离氨基酸水平的研究[J].中国优生优育(1990-2002上半年),1998,9(2):63-66. 被引量:7
  • 7Goyett P, Sumner JS,Frosst P, et al.Human methylenetetrahy- drofolate reductase:Isolation of cDNA,mapping and mutation identification[J] .Nature Genetics, 1994,7(4): 195-200.
  • 8Blom HJ, Shaw GM,den Heijer M, et al.Neural tube defects and folate: case for from closed[J]. Nat Rev Neurosci,2006,7(9): 724-731.
  • 9Engbersen AM,Franken DG,Boers GH,et al.Therrnolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia[J].Am J Hum Genet,1995,56(1): 142-150.
  • 10Hanson NQ,Aras O,Yang F,et al.C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene:incidence and effect of combined genotypes on plasma fasting and post-methionine load homocysteine in vascular disease[J].Clin Chern,2001, 47(4):661-666.

二级参考文献15

  • 1刘向东,陈亚华,常虹,唐仪,李竹,李继芬,冯建强,鞠凤芝,张国忠,李蓉,金书,陈华,祁竹萍,胡本祥.神经管畸形不同发病地区和季节婚检妇女膳食蛋氨酸含量的对比研究[J].中国优生优育(1990-2002上半年),1995,6(3):104-106. 被引量:1
  • 2朱慧萍,李竹,王秋枫,赵树芬,张秀池.小牛血清培养基中增补蛋氨酸促进大鼠胚胎神经管闭合[J].北京医科大学学报,1996,28(5):347-349. 被引量:2
  • 3Elwood JM, Elwood JH. Epidemiology and control of neural tube defects [M]. London: Oxford University Press, 1992:80.
  • 4Davidoff M J, Petrini J, Damus K,et al. Neural tube defect -specific infant mortality in the United States [ J ]. Teratology, 2002,66 ( Suppl 1 ) :S17.
  • 5Copp A J, Greene ND, Murdoch JN. The genetic basis of mammalian neurulation [J] .Nat Rev Genet, 2003, 4 (10): 784.
  • 6Steegers- Theunissen RPM, Boers GH, Trijbels JF, et al. Neural tube defects and derangement of homocysteine metabolism [ J ]. N Eng J Med, 1991, 324 (3): 199.
  • 7Finkelstein JD. Methionine metabolism in mammals [ J ]. J Nutr Biochem, 1990, 1 (5): 228.
  • 8Bohles H, Amdt S, Ohlenschlager U, et al. Maternal plasma homocysteine, placenta status and docosahexaenoic acid concentration in erythrocyte phospholipids of the newborn[J]. EurJ Pediatr,1999,158(3) .243.
  • 9Blom HI, Shaw GM, Den Heijer M, et al. Neural tube defects and folate: case far from closed[J]. Nat Rev Neurosci,2006,7(9) :724.
  • 10Kirke PN, Molloy AM, Daly LE, et al. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects [J] . Q J Med, 1993, 86 (11): 703.

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