摘要
目的探讨慢性阻塞性肺疾病(COPD)患者检测纤维蛋白原降解产物(FDP)和抗凝血酶-Ⅲ(AT-Ⅲ)的意义。方法选取COPD患者共120例,其中Ⅰ级组30例,Ⅱ级组30例,Ⅲ级组32例,Ⅳ级组28例,以同期进行健康体检的100例健康人群作为对照组,COPD患者及健康体检者均抽取外周静脉血3ml,采用全自动血凝仪检测凝血酶原时间(PT)和凝血酶时间(TT),采用ELISA法检测FDP,采用免疫浊度法测定AT-Ⅲ。结果 COPDⅠ～Ⅳ级患者的TT、PT与对照组比较差异均无统计学意义(P>0.05)。COPDⅠ～Ⅳ级患者FDP水平均显著高于对照组(P<0.01),AT-Ⅲ水平均显著低于对照组(P<0.01),并且各级COPD患者AT-Ⅲ水平比较差异均有统计学意义(P<0.01)。COPDⅠ～Ⅳ级患者FDP和AT-Ⅲ水平存在显著的负相关(r=-0.954,P<0.01)。结论 FDP和AT-Ⅲ检测对于COPD患者有无凝血功能障碍的监测实用性较强。
Objective To explore the significance of detecting FDP and AT-Ⅲ in patients with chronic obstruc- tive pulmonary disease（COPD）. Methods 120 patients with COPD were divided into Group Ⅰ （30 cases） , Group Ⅱ（30 cases）,GroupⅢ（32 cases） and Group Ⅳ （28 cases）. 100 healthy check-up people were selected as the control group. 3 ml of peripheral venous blood was drawn from each of COPD patients and healthy check-up people. PT and TT of each group were detected by the hematopexis equipment and FDP was measured by ELISA,AT-Ⅲ by immuno- blot assay. Results Patients with COPD from Group Ⅰ to Group Ⅳ had much higher level of FDP,obviously lower level of AT-Ⅲ than the control group（ P 〈0.05） while their TT and PT had no statistical difference（ P 〉0.05）. The difference of AT-Ⅲof every group was significant（ P 〈0.05）. The AT-m and FDP level of each group was in nega- tive relevance from Group Ⅰ to Group Ⅳ （ r = -0. 954, P 〈0.0l）. Conclusion FDP and AT- Ⅲ are useful for diag- nosis of hematopexis disorder in patients with chronic obstructive pulmonary disease.
出处
《右江医学》
2012年第4期484-486,共3页
Chinese Youjiang Medical Journal
