老年脑梗死与颈动脉斑块及超敏反应C蛋白的相关性分析

Correlation Analysis of Elderly Cerebral Infarction with Carotid Plaque and Hypersensitivity C Protein

目的探讨老年脑梗死与颈动脉粥样硬化(CAS)斑块及超敏反应C蛋白(CRP)水平的关系。方法对100例老年急性脑梗死患者进行颈动脉颅外段彩色多普勒(TCD)检查,观察血管内斑块状况,同时检测血CRP水平,将同期健康体检者80例设为对照组,观察两者的差别并进行分析。结果实验组斑块检出率为74%,对照组17.5%,两者有显著性差异(P<0.01)。斑块好发于颈动脉分叉处,以硬斑为主,但实验组软性斑块明显高于对照组(P<0.01);血清CRP水平实验组明显高于对照组(P<0.01),软性斑块患者CRP含量高于硬性斑块患者。结论老年脑梗死与颈动脉粥样硬化斑块有密切关系,软性斑块的存在、血CRP增高,都是老年脑梗死的重要危险因素,值得临床重视及早期干预。

Objective To explore the relationship between the elderly cerebral infarction with carotid atherosclero- sis （CAS） plaque and hypersensitivity C protein （CRP） level. Methods 100 elderly patients with acute cerebral infarction are examined by the carotid extracranial color Doppler （TCD）, which can observe the intravascular plaque status, and are detected with blood CRP levels. 80 healthy persons during the same period served as con- trols. Observe and analyze the difference between the two groups. Results The plaque detection rate in the experi- mental group was 74% , only 17.5% in the control group. There are significant differences （P 〈 0. 01 ） between them ; plaques occur in the carotid bifurcation , mainly morphea , but soft plaque in the experimental group was significantly higher than the control group （ P 〈 0. O1 ） ; serum CRP levels in the experimental group was signifi- cantly higher （P 〈 0.01 ） , the CRP levels is higher in patients with soft plaque than in patients with hard plaque. Conclusion Elderly cerebral infarction is closely related to carotid artery atherosclerotic plaque. The presence of soft plaque, the increase of blood CRP are important risk factors for senile cerebral infarction, is worthy of atten- tion and early intervention.