前列地尔注射液对急性脑梗死患者的疗效及对平均血小板体积和血浆纤维蛋白含量的影响

Efficacy of Alprostadil Injection for Acute Cerebral Infarction and Its Effects on Mean Platelet Volume and Plasma Fibrinogen

目的:观察前列地尔注射液对急性脑梗死患者的疗效及对平均血小板体积和血浆纤维蛋白含量的影响。方法:将120例急性脑梗死患者以随机抽样法分为治疗组和对照组,对照组(60例)采用常规治疗;治疗组(60例)在常规治疗的基础上加用前列地尔注射液(10μg,1日1次)静脉滴注,于治疗前以及治疗14 d后评定治疗效果、平均血小板体积(MPV)和血浆纤维蛋白原(FIB)含量。结果:治疗组显效率(28/60,46.67%)明显高于对照组(13/60,21.67%),差异有统计学意义(P<0.05);治疗组MPV较治疗前有明显的降低,降低的幅度明显多于对照组,P<0.05;治疗组FIB较治疗前有明显的降低,降低的幅度明显多于对照组,P<0.05。结论:前列地尔可能通过降低平均血小板体积和血浆纤维蛋白含量来改善患者血液高凝的状态,对脑梗死患者有一定的积极治疗作用。

OBJECTIVE：To observate the effects of alprostadil injection for acute cerebral infarction and on mean platelet volume（MPV） and plasma fibrinogen level.METHODS： 120 patients with acute cerebral infarction were randomly divided into either control group（n=60） receiving conventional therapy or treatment group（n=60） treated with add-on alprostadil injection（10 μg once a day） by intravenous drip infusion.The therapeutic efficacy,MPV and plasma fibrinogen level were evaluated at 0 and 14 days,respectively.RESULTS： The excellent response rate in the treatment group was significant higher than in the control group（46.66% vs.21.67%） and the differences were statistically significant（P〈0.05）.After treatment,the treatment group showed significantly greater reduction in MPV and plasma fibrinogen than did the control group（P〈0.05 for both）.CONCLUSION： Alprostadil may improve hypercoagulable state by reducing the mean platelet volume and plasma protein fibrinogen level,and it plays a positive role in the treatment of patients with cerebral infarction.