奥美沙坦酯与缬沙坦对原发性高血压患者血压晨峰的影响

The effect of olmesartan medoxomil and valsartan on blood pressure morning surge of patients with primary hypertension

目的比较奥美沙坦酯和缬沙坦治疗高血压患者血压晨峰的疗效。方法选择我院76例原发性高血压患者随机分为2组，分别接受奥美沙坦酯20-40mg／d或缬沙坦80-160mg／d治疗，共8周，观察服药前及服药后清晨血压变化。结果奥美沙坦酯组和缬沙坦组治疗后晨峰血压均有明显下降，与治疗前比较差异有统计学意义（P〈0．05）。奥美沙坦酯组和缬沙坦组晨峰血压下降的幅度分别为：／kSBP（10．22±0．35）mmHg、（5．63±0．21）mmHg；△DBP（7．71±0．29）mmHg、（3．55±0．14）mmHg，奥美沙坦酯组血压晨峰下降幅度高于缬沙坦组，差异有统计学意义（P〈0．05）。结论奥美沙坦酯和缬沙坦均可以有效地控制原发性高血压患者血压晨蜂现象，奥美沙坦酯优于缬沙坦。

Objective To evaluate the efficacy of olmesartan medoxomil and valsartan on blood pressure morning surge of patients with primary hypertension. Methods 76 patients with primary hypertension were ran- domized divided into olmesartan medoxomil group （olmesartan medoxomil 20-40 mg） and valsartan group（valsartan 80-160 mg）, once daily for 8 weeks, then the variety of blood pressure morning surge was analyzed. Results The blood pressure morning surge was significantly declined in both olmesartan medoxomil group and valsartan group compared with baseline （P〈0.05）. There were significant differences in blood pressure morning surge be- tween olmesartan medoxomil group [ A SBP （ 10.22＋0.35 ）mm Hg, A DBP （7.71 ＋0.29 ）ram Hg ] and valsartan group [ △SBP （5.63±0.21）mm Hg, △DBP （3.55±0.14）mm Hg]. The olmesartan medoxomil group showed a significant decline in blood pressure morning surge compared with valsartan group （P〈0.05）. Conclusion Olmesartan medoxomil and valsartan show great therapeutic effect on blood pressure morning surge, and olmesartan medoxomil is better than valsartan.