期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基质金属蛋白酶-13及其与恶性肿瘤侵袭转移的关系研究进展 被引量：2

原文传递
导出
摘要 恶性肿瘤侵袭转移是一个复杂的病理过程,细胞基底膜和细胞外基质(extracellular matrix,ECM)降解是其侵袭转移及复发的关键。基质金属蛋白酶-13(matrix metalloproteinases-13,MMP-13)是基质金属蛋白酶超家族成员中胶原酶的一种,主要功能是分解ECM,并与人体多种生理和病理过程相关。本文结合近年来临床和基础研究的相关成果,从MMP-13相关的基础研究出发,就其与肿瘤侵袭转移的关系综述如下。
作者 马若飞 张成武
机构地区 青海大学医学院 青海大学附属医院
出处 《社区医学杂志》 2012年第16期47-49,共3页 Journal Of Community Medicine
关键词 金属基质蛋白酶-13 恶性肿瘤 肿瘤侵袭转移
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献18

  • 1Airola K, Karonen T, Valarao M, et al. Expression of collagenases - 1 and -3 and their inhibitors TIMP - 1 and -3 correlates with the lev- el of invasion in malignant melanomas. British Journal of Cancer, 1999,80(5/6) :733 - 743.
  • 2Michael Elkin, Hana Ariel, Hua - Quan, et al. Inhibition of Bladder Carcinoma Angiogenesis, Stromal Support, and Tumor Growth by Halofuginone[ J ]. CANCER RESEARCH, 1999,59:4111 -4118.
  • 3Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases : regu- lators of the tumor microcnvironment[ J], Cell,2010,141 (1) :52 - 67.
  • 4Klelner DE, Stetler - Stevenson WG. Matrix Metalloproteinases and Metastasis [ J ]. Cancer Chemother Pharmacol, 1999,43 ( Suppl ) : 42 -51.
  • 5Freijc JM, Diez itza I, Balbha M, et al. Molecular cloning and expres- sion of collagenase -3, a novel human matrix metalloproteinase pro- duced by breast carcinomas [ J ]. J Biol Chem, 1994,269 ( 24 ) : 16766 - 16733.
  • 6Lecman MF, Curran S, Murray GI. The structure, regulation, and function of human matrix metalloproteinase - 13 [ J ]. Critical Re- views in Biochemistry and Molecular Biology, 2002,37 ( 3 ) : 149 - 166.
  • 7Witty JP,Foster SA, Stricklin GP, et al. Parathyroid hormone -in- duced resorption in fetal rat limb bones in associatecl with produltionof the metalloproteinases eollagenase and galatinase B[ J]. J Bone Miner Res, 1996, Jan, 11 ( 1 ) :72 - 78.
  • 8Balbin M, Pendas AM, Uria JA, et al. Expression and regulation of eollagenase - 3 ( MMP - 13 ) in human malignant tumors[ J]. AP- MIS,1999,107(1) :45 -53.
  • 9Heppner K J, Matrisian LM, Jensen RA,et 8.1. Expression of most ma- trix metalloproteinase family members in breast eaneer represents a tumor - induced host responsel[J]. Am J Pathol, 1996,149 ( 1 ) : 273 -282.
  • 10Uria JA, Stahlc - Backdahl M, Seiki M, et al. Regulation of collage- nase- 3 expression in human breast carcinomas is mediated by stromal - epithelial cell interactions [ J ]. Cancer Res, 1997,57 (21) :4882 -4888.

二级参考文献21

  • 1Fosang A J, Last K, Knauper V, et al. Degradation of cartilage aggrecan by collagenase-3 (MMMP-13). FEBS Lett, 1996,380(1-2): 17-20.
  • 2Knauper V,Cowell S,Smith B, et al. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. J Biol Chem, 1997,272(12) :7608-7616.
  • 3Ashworth JL, Murphy G, Rock M J, et al. Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodeling. Biochem J,1999,340(Ptl): 171-181.
  • 4Itoh F, Yamamoto H, Hinoda Y, Imai K. Enhanced secretion and activation of matrilysin during malignant conversion of human colorectal epithelium and its relationship with invasive potential of colon cancer cells. Cancer, 1996,77(8 suppl): 1717-1721.
  • 5Yoshimoto M,Itoh F, Yamamoto H, et al. Expression of MMP-7 (pump-1)mRNA in human colorectal cancers. Int J Cancer, 1993,54(4 ): 614-681.
  • 6Schwingshackl A,Duszyk M,Brown N,et al. Human eosinophils release matrix metalloproteinase-9 on stimulation with TNF-alpha. J Allergy Clin Immunol, 1999,104 (5): 983-989.
  • 7Michael M, Babic B, Khokha R, et al. Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer. J Clin Oncol, 1999,17(6): 1802-1808.
  • 8Stetler-Stevenson WG, Liotta LA, Kleiner Jr DE. Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis. FASEB J, 1993, 7 (15) : 1434-1441.
  • 9Knauper V, Cowell S, Smith B, et al. The role of the C-terminal domain of human eollagenase-3 (MMP-13) in the activation of proeollagenase-3. J Biol Chem, 1997, 272:7608-7616
  • 10Knauper V, Lopez-Otin C, Smith B, et al. Biochemical characterisation ofhuman collagenase-3. J Biol Chem, 1996, 271:1544-1550

共引文献4

同被引文献29

引证文献2

二级引证文献69

社区医学杂志
2012年 第16期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部