酪酸梭菌二联活菌散治疗婴幼儿肺炎继发腹泻的临床观察

目的:观察酪酸梭菌二联活菌散(常乐康)治疗婴幼儿肺炎继发腹泻的临床疗效。方法:将156例婴幼儿肺炎继发腹泻患儿随机分为治疗组及对照组各78例,两组均给予抗感染及对症治疗。治疗组在对照组治疗基础上给予口服酪酸梭菌二联活菌散,<1岁250mg/次,>1岁500mg/次,3次/日,观察治疗后两组临床症状和体征消失时间、住院时间及治疗后第3、5、7天的有效率。结果:治疗组在循环不良消失时间、呕吐消失时间、住院时间等方面显著低于对照组(P<0.05),两组退热时间比较差异无统计学意义(P>0.05);治疗组在治疗后第3、5、7天的总有效率分别为79.49%、87.18%、96.15%,显著高于对照组的51.28%(P<0.01)、58.97%(P<0.01)、79.49%(P<0.05),两组比较差异均有统计学意义。结论:酪酸梭菌二联活菌散能有效减轻肺炎继发腹泻的临床症状,缩短病程。

Objective： To observe the clinical effect of clostridium butyricum and bifid bacterium powder in the treatment of sec- ondary diarrhea in pneumonic infants. Meth- ods： 156 cases of pneumonic infants with secondary diarrhea were randomly divided into a treatment group and a control group. Each group included 78 cases. Both groups were given anti -infection and symptomatic treatment. The treatment group was given clostridium butyricum and bifid bacterium powder, 〈 1 year old 250mg each time, 〉 1 year old 500mg each time, 3 times a day. The disappearance time of clinical symptoms and the length of hospitalization were ob- served. Patients＇ developments were also ob- served on day 3,5,7. Results：In the treat- ment group, the duration of poor circulation （ P 〈 O. 05 ）, vomiting （ P 〈 0.01 ） , and hos-pitalization （ P 〈 0. 05 ）, were significantly shorter than those in the control group. The duration of fever had no statistically signifi- cant difference （ P 〉 0.05 ）. The total effec- tive rates on day 3,5,7 after treatment, were79. 49%, 87. 18% and 96. 15% in treatment group, which was significantly higher than those in the control group （51. 28%, 58. 97% and 79. 49%）. Conclu- sions：The clostridium butyricum and bifid bacterium powder can effectively reduce the clinical symptoms of secondary diarrhea in pneumonic infants and shorten the duration.