摘要
目的:分析血清胱抑素C(CysC)和尿白蛋白排泄率(UAER)的联合检测与原发性高血压患者早期肾损害的相关性。方法:用全自动生化分析仪测定286例原发性高血压患者早期肾损害血清胱素C、尿白蛋白、血清肌酐浓度。结果:原发性高血压患者早期损害血清CysC和UAER浓度均高于对照组(P<0.05),两者联合检测的阳性率显著高于单检CysC或单检UAER的阳性率(P<0.01)。结论:原发性高血压患者早期的血清CysC和UAER浓度均显著高于对照组(P<0.05),采用血清CysC和UAER联合检测的阳性检出率较之单项检测显著增加(P<0.01),从而有助于及早发现原发性高血压患者早期肾损害,具有重要的临床诊断意义。
Objective： to analyze the correlation between the joint detection of CysC and UAER and early renal damage in patients with primary hypertension. Method：test concentrations of cysatin C, urinary albumin and serum creatinine of early renal damage in 286 patients with primary hypertension by means of an automatic biochemical analyzer. Result： the concentrations of CysC and UAER of early renal damage in patients with primary hypertension are higher than those in control group （ P 〈 0.05 ） ; the positive rate by joint detection is remarkably higher than that by single detection CysC or UAER （ P 〈 0.01 ）. Conclusion： the concentrations of CysC and UAER of early renal damage in patients with primary hypertension are higher than those in control group （ P 〈 0.05 ） ; the positive detection ratio using joint detection of CysC and UAER is apparently increased compared with that using the single detection（ P 〈 0. 01 ） ; therefore, it is helpfulto find early renal damage in patients with primary hypertension and is of important clinical significance.
