微通道内载紫杉醇固体脂质纳米粒制备及工艺优化

Preparation of Paclitaxel-loaded Solid Lipid Nanoparticles in Microchannels and Formulation Optimization

目的:制备载紫杉醇固体脂质纳米粒。方法:微通道内采用溶剂扩散法制备脂质纳米粒,并通过正交优化制备工艺。结果:制备的纳米粒稳定性良好,平均粒径为(129.87±2.91)nm,包封率为(3.11±0.06)%,载药率为(43.67±0.24)%。结论:本研究制备的载药固体脂质纳米粒载药特性与重复性良好。

Objective： To prepare paclitaxel loaded solid lipid nanoparticles（SLNs） with proper physicochemical property by rectangular microchannels.Methods： Paclitaxel loaded solid lipid nanoparticles（PTX-SLNs） was prepared by solvent diffusion method in rectangular microchannels.Orthogonal design was utilized to optimize prescription.Result： PTX-SLNs prepared with optimized prescription demonstrated good stability.The encapsulation efficiency and drug loading of PTX-SLNs were（43.67±0.24） % and（3.11±0.06） % respectively,the average size was（129.87±2.91） nm.Conclusion： PTX-SLNs has a good medicine characteristics and reproducibility.