腹腔镜下子宫体三角形切除术对卵巢功能影响研究

Study on Impact of Laparoscopic Triangle Hysterectomy on Ovarian Function

目的探讨腹腔镜下子宫体三角形切除术对卵巢功能的影响。方法前瞻性收集2007年1月-2010年12月本院因功血行腹腔镜下子宫体三角形切除术40例,随机选取因功血腹腔镜下子宫体全切40例,比较术前和术后三个月基础卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、抑制素B(inhibin B)和抗苗勒管因子(AMH)。结果腹腔镜下子宫体三角形切除术术前术后FSH、LH、E2I、nhibin B和AMH差异无统计学意义,腹腔镜下子宫体切除术术后FSH、E2明显升高,Inhibin B、AMH明显降低,术后三个月腹腔镜下三角形切除术与腹腔镜下子宫体全切术相比FSH、E2明显降低,Inhibin B、AMH明显升高。结论腹腔镜下子宫体三角形切除术比腹腔镜下子宫体全切术更好地保护卵巢。

Objective To explore the effect of laparoscopic triangle hysterectomy on ovarian function. Methods We prospectively and randomly collected 40 patients underwent laparoscopic triangle hysterectomy and 40 patients underwent total hysterectomy due to dysfunctional uterine bleeding hospitalized in Zhuhai Municipal Maternal and Child Health Hospital from Jan- uary 2007 to December 2010. Follicle- stimulating hormone （FSH）, luteinizing hormone （LH）, estradiol （E2）, inhibin B and anti - mullerian hormone （AMH） were detected and compared before and three months after the surgery. Results No statis- tically significant difference was found in FSH, LH, E2, inhibin B and AMH of laparoscopic triangle hysterectomy group between before and after the surgery. Three months after the surgery, FSH and E2 in total hysterectomy group were significantly in- creased, while inhibin B and AMH were significantly decreased. As compared with total hysterectomy group, FSH and E2 of lap- aroscopic triangle hysterectomy group were significantly decreased, while inhibin B and AMH were significantly increased three months after the surgery. Conclusions Laparoscopic triangle hysterectomy is superior to total hysterectomy in the protection of ovarian function.