耐甲氧西林金黄色葡萄球菌流行病学分析及耐药性研究

Epidemiological Analysis of Methicillin-resistant Staphylococcus aureus and Study on Its Drug Resistance

目的了解近5年来邵阳市中心医院耐甲氧西林金黄色葡萄球菌(MRSA)感染的流行病学及耐药情况。方法对该院2006年1月-2010年12月收集的10 215份不同标本培养结果进行回顾性统计分析,分析MRSA检出率及药敏情况。结果在10 215份不同标本中,检出耐甲氧西林菌株1 195株,占检出细菌的18.45%(1 195/6 476),其分离率有逐年增长的趋势。MRSA对临床常用多种抗生素的耐药率为80%以上,对万古霉素及替考拉宁的敏感率为100%。结论 MRSA发生率呈逐年上升趋势,且呈现多重耐药,应加强抗菌药物的合理应用,减少MRSA耐药的发生。

Objective To investigate the epidemiology of methicillin- resistant Staphylococcus aureus （MRSA） infection and its drug resistance, which isolated from the Central Hospital of Shaoyang City in the recent five years. Methods The bacterial culture results of 10,215 different specimens from inpatients of the hospital from January 2006 to December 2010 were retrospectively analyzed. The detection rate of MRSA and its drug resistance were also analyzed. Results Altogether 1,195 strains of MRSA were i^lated from 10,215 different specimens, accounted for 18.45 % of the detected bacteria （1,195/6,476）, and the isolation rate of MRSA was increasing year by year. The resistant rates of MRSA against commonly used antibiotics were above 80%, but the sensitive rates of MRSA to vancomycin and teicoplanin were both 100%. Conclusions The incidence of MRSA infection shows an upward trend within these years, and moreover, its antibiotic resistance is multiple. We should strengthen the rational use of antibiotics .so as to reduce the occurrence of drug resistance of MRSA.