血小板、纤维蛋白原水平与缺血性脑卒中关系的临床研究

Clinical Study on the Relationships Between Plasma Platelet and FIB Levels and Cerebral Ischemic Stroke

目的探讨缺血性脑卒中与血小板、血浆纤维蛋白原之间关系。方法选取缺血性脑卒中患者235例和健康者156例,进行血小板(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)及纤维蛋白原(FIB)水平检测。在入院时和出院后6个月分别评价脑卒中组患者的血小板和纤维蛋白原水平,并给予为期2年的随访。结果缺血性脑卒中组与健康组比较,MPV、PDW、FIB明显升高(P<0.05),PLT明显降低(P<0.05);患者的纤维蛋白原水平和神经功能损伤之间具有明显的相关性(r=0.761,P<0.05)。结论观察PLT、MPV、PDW及FIB水平变化对病情诊断和病情判断具有重要的指导意义。

Objective To investigate the associations between the levels of plasma platelet （PLT） and fibrinogen （FIB） and cerebral ischemic stroke. Methods The levels of plasma PLT, mean platelet volume（MPV）, platelet distribution width （PDW） and FIB in the blood were measured in 235 patients with cerebral ischemic stroke and 156 healthy controls. The PLT and FIB levels in the patients with cerebral ischemic stroke were evaluated on admission and six months after discharge and were followed up for two years. Results Compared with those in the control group, the levels of plasma MPV, PDW and FIB were significantly increased in the cerebral ischemic stroke group （P〈 0.05）, while the level of PLT was markedly decreased （P〈 0.05 ）. A statistical correlation was revealed between the serum FIB level and the neurologic impairment （r = 0. 761, P 〈0.05）. Conclusions The measurements of the PLT, MPV, PDW and FIB are of clinical significance to the diagnosis and judgment of the conditions of cerebral ischemic stroke.