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针对胃肠道黏液屏障的口服纳米粒研究进展 被引量：3

Oral Nanoparticles: The Gastrointestinal Mucus Barriers
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摘要 本文主要针对胃肠道黏液的屏障作用,系统阐述了黏液对口服纳米粒药物吸收的影响,以及克服胃肠道黏液屏障的口服纳米粒的研究进展。 This paper describes the barrier function of the gastrointestinal tract mucus, how the mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier.
作者 杨晖 姚静 周建平 李苏昕
机构地区 中国药科大学药剂学教研室
出处 《药学与临床研究》 2012年第4期339-342,共4页 Pharmaceutical and Clinical Research
基金 国家基础科学人才培养基金项目号(J0630858) 省级大学生实践创新训练计划项目资助
关键词 胃肠道黏液 吸收屏障 口服纳米粒 Gastrointestinal mucus Absorption barriers Oral nanoparticles
分类号 R944.9 [医药卫生—药剂学]
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参考文献25

  • 1Plapied L, Duhem N, des Rieux A, et al. Fate of polymeric nanocarriers for oral drug delivery [J]. Curr Opin Colloid Interface, 2011(16): 228-37.
  • 2Cone RA. Barrier properties of mucus [J]. A dv Drug Deliv Rev, 2009, 61 (2): 75-85.
  • 3Lai SK, Wang YY, Hanes J. Mucus -penetrating nanoparticles for drug and gene delivery to mucosal tissues[J]. Adv Drug Deliv Rev, 2009, 61(2): 158-71.
  • 4Suk JS, Lai SK, Boylan N J, et al. Rapid transport of muco -inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine [J]. Nanomedicitre, 2011, 6(2): 365-75.
  • 5Suk JS, Lai SK, Wang YY, et al. The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles[J]. Biomaterials, 2009, 30(13): 2591-7.
  • 6Tang BC, Dawson M, Lai SK, et al. Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier [J]. Proc Natl Acad Sci USA, 2009, 106 (46): 19268-73.
  • 7Yang M, Lai SK, Wang YY, et al. Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus [J]. Angew. Chem. Int. Ed, 2011, 50(11): 2597-600.
  • 8Park JH, Saravanakumar G, Kim K, et al. Targeted delivery of low molecular drags using chitosan and its derivatives[J]. Adv. Drug Deliv Rev, 2010, 62(1): 28-41.
  • 9Roger E, Lagarce F, Garcion E, et al. Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery [J]. Nanomedicine, 2010, 5(2): 287-306.
  • 10Wilson DS, Dalmasso G, Wang LX, et al. Orally delivered thioketal nanoparticles loaded with TNF-alpha-siRNA target inflammation and inhibit gene expression in the intestines[J]. Nat Mater, 2010, 9 (11): 923-8.

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药学与临床研究
2012年 第4期

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