大理地区志贺菌的血清型分布及耐药性分析

Study on Serotype Distribution and Drug Resistance of Shigellae in Dali

目的:了解大理地区志贺菌的血清型分布及对12种常用抗生素的耐药性。方法:通过分离培养和鉴定得到68株志贺菌,血清学鉴定其血清型,K-B法检测其对12种抗生素的敏感性。结果:血清学鉴定显示68株志贺菌中福氏志贺菌41株,宋内氏志贺菌25株,鲍氏志贺菌2株。志贺菌对萘啶酸耐药率最高,对复方磺胺甲噁唑和氨苄西林耐药率较高;对头孢曲松和头孢噻肟较敏感,对喹诺酮类显示出不同程度的耐药。结论:大理地区以福氏志贺菌感染为主。在志贺菌治疗中可首选头孢曲松和头孢噻肟。

Objective： To investigate the serotype distribution of Shigellae in Dali and evaluate the resistance of Shigellae to 12 common used drugs. Methods： Serotypes of 68 isolated and identified strains of Shigellae were measured. K-B test was applied to define the drug-resistance of Shigellae to 12 different drugs. Results： Among 68 strains examined, 41 were Shigella Flexner, 25 were Shigella sonnei and 2 were Shigella boydii identified by serotype. Shigellae showed the highest drug resistance to nalidixic acid, with followed sulfalene and nalidixic and varying extents of drug resistance to quinolones; Shigellae was sensitive to ceftriaxone and cefotaxime. Conclusion： These results suggest that Shigella Flexner is the main infection strains in Dali and ceftriaxone and cefotaxime should be preferred in the treatment with Shigellae.