2型糖尿病患者RBP4水平与颈动脉粥样硬化的关系

The Relationship between RBP4 and Carotid Atherosclerosis in Patients with Type2 Diabetes Mellitus

目的探讨2型糖尿病(T2DM)患者血清视黄醇结合蛋白4(RBP4)水平与颈动脉粥样硬化(AS)的关系。方法 T2DM患者148例,按超声诊断仪测量的颈动脉内膜中层厚度(IMT)结果和粥样斑块将其分三组:非IMT增厚组46例I、MT增厚组53例和斑块形成组49例,并选择健康体检者50例作为对照组,分别检测身高、体重、血脂、血糖、空腹胰岛素、RBP4,并计算BMI及IR,分析其相关性。结果 T2DM患者组血清RBP4水平均高于对照组(P<0.05),非IMT增厚组I、MT增厚组和斑块形成组组间比较差异有统计学意义(P<0.05);T2DM患者各组的RBP4水平与BMI、TG、HOMA-IR呈正相关,IMT增厚组和斑块形成组的RBP4水平与IMT呈正相关;Logistic回归分析显示血清RBP4水平是IMT值的独立相关因素。结论血清RBP4水平升高是T2DM患者颈动脉内膜增厚的主要危险因素,与颈动脉粥样硬化发病关系密切。

Objective To evaluate the relationship between RBP4 in patients of T2DM and AS and the clinical significance. Methods 148 T2DM patients were divided into 3 groups： Non-IMT thicken group （46 patients）, IMT thicken group （53 patients） and plaque formation group （49 patients） . Serum sample were taken from these 148 T2DM patients and 50 normal controls. RBP4 was measured with ELISA, and we also measured height, weight, blood lipids, blood glucose, fasting insulin, and calculate BMI and IR. Spear- man analysis and Logistic regression analysis were used. Results The patients with T2DM had significantly higher levels of RBP4 than control group （＇all P 〈 0.05）, the difference between Non-IMT thickening group, IMT thickening and plaque formation group were statistically significant （all P 〈 0.05） ; RBP4 levels of T2DM groups was positively correlated with BMI, TG, HOMA-IR, RBP4 level of IMT thickening and plaque fomlation group was positively correlated with 1MT; Logistic regression analysis showed that serum RBP4 levels are independently associated with IMT values. Conclusions Serum RBP4 levels elevated in T2DM patients was the major risk factor for carotid artery endometfial thickening, and it may play an important role in the development of atherosclerosis.