期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

T细胞激活和凋亡信号的识别与传递机制 被引量：2

下载PDF
导出
摘要 1关于T细胞识别激活和凋亡信号的研究回顾淋巴细胞的识别与激活是免疫应答的核心问题，也是近半个世纪来免疫学和细胞生物学研究的热点问题之一。1970年已经发现抗体的生成需要至少2种淋巴细胞（T细胞和B细胞）协同作用。1977年MHC限制现象被发现，证明了所有能被激活的T细胞必定受限于特定主要组织相容性复合体（MHC）等位基因产物。即存在抑制性T细胞（Ts）的调节作用，
作者 陈雪晴
机构地区 复旦大学生命科学学院
出处 《天津中医药》 CAS 2012年第4期413-416,共4页 Tianjin Journal of Traditional Chinese Medicine
关键词 T淋巴细胞 激活和凋亡 信号通路 调节机制
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献23

  • 1Lu Q, Wu A, Richardson BC. Demethylation of the same promoter sequence increases CD70 expression in lupus T-cells and T-cells treated with lupus-inducing drugs[J]. J Immunol, 2005, 174: 6212- 6219.
  • 2于善谦,王洪海,朱乃硕,等.免疫学导论[M].北京:高等教育出版社.2010:197—198.
  • 3Chang S, Aune TM. Dynamic changes in histone methylation marks across the locus encoding interferon-gamma during the differentia- tion of T helper type2 cells[J]. Nat Immunol, 2007, 8(7): 723-731.
  • 4Hervas-Stubbs S, Olivier A, Boisgeranh F, et al. TLR3 ligandstimu- lares fully functional memory CD8 1" cells in the absence of CD4 T-cell help[J]. Blood, 2007, 109( 12): 5318-5326.
  • 5Williams MA, Ravkov EV, Bevan MJ. Rapid culling of the CD4 T- cell repertoire inthe transition from effector to memory[J]. Immunity, 2008, 28(4):533-545.
  • 6Julien van Greveny nghe. Francesc AProcopio, Zhong he, et al. Tran- scription factor FOXO3 eontrols the persistence of memory CD4(+) T-cells during HIV infection[J]. Nat Ned, 2008, 14(3): 266-274.
  • 7Esteller M. Cancer epigenomics: DNA methylomes and histone mod- ification maps[J]. Nat Rev Genet, 2007, 8: 286-298.
  • 8张静,刘彦信,刘士廉,郑德先.PI3K/Akt信号传递途径与CD3ε介导T淋巴细胞激活和凋亡的调控[J].科学通报,2000,45(20):2201-2204. 被引量：1
  • 9PurtonJ F, TanJ T, Rubinstein MP, et al. Antiviral CD4 memory T- cells are IL-15 dependent[J]. J ExpMed, 2008, 204(4): 951-961.
  • 10Halle A, Homung V, Petzold G C, et al. The NALP3 inflanunome is involved in the innate immune response to amyloid213[J]. Nat Im- munol, 2008, 9(8): 857-865.

二级参考文献81

  • 1Henrickson S E,von Andrian U H. Single-cell dynamics of T- cell priming [J]. Curt Opin Immunol,2007,19(3):249-258.
  • 2Tey S K,Bollard C M, Heslop H E. Adoptive T-cell transfer in cancer immunotherapy [J]. Immunol Cell Biol, 2006,84 ( 3 ) : 281-289.
  • 3Leen A M, Heslop H E. Cytotoxic T lymphocytes as immune therapy in haematological practice [J]. Br J Haematol, 2008, 143(2) : 169-179.
  • 4Lenz L L,Butz E A,Bevan M J. Requirements for bone marrow-derived antigen-presenting cells in printing cytotoxic T cell responses to intracellular pathogens [J]. J Exp Med, 2000,192 (8):1135- 1142.
  • 5Sigal L J, Rock K L. Bone marrow derived antigen presenting cells are required for the generation of cytotoxic T lymphocyte responses to viruses and use transporter associated with antigen presentation (TAP)-dependent and -independent pathways of antigen presentation [J]. J Exp Med, 2000, 192(8) : 1143- 1150.
  • 6den Haan J M,Bevan M J. Antigen presentation to CD8^+ T cells: cross-priming in infectious diseases [J]. Curr Opin Immu nol,2001,13(4) :437 441.
  • 7Cai Z,Sprent J. Influence of antigen dose and costimulation on the primary response of CD8^+ T cells in vitro [J]. J Exp Med, 1996,183(5) :2247- 2257.
  • 8Alexander Miller M A, Leggatt G R,Sarin A,et al. Role of antigen,CD8,and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL [J]. J Exp Med,1996,184(2):485 -492.
  • 9Storni T,Bachmann M F. On the role of APC-activation for in vitro versus in vivo T cell priming [J]. Cell Immunol,2003,225 (1):1- 11.
  • 10Ludewig B, K rebs P, J unt T, et al. Determining control parameters for dendritic cell-cytotoxic T lymphocyte interaction [J]. Eur J Immunol,2004,34(9) :2407-2418.

共引文献10

同被引文献52

引证文献2

二级引证文献2

天津中医药
2012年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部