辛伐他汀对冠心病患者血清内脂素水平的影响

Effect of simvastatin on the serum levels of visfatin in patients with coronary artery disease

目的:研究冠心病患者血清内脂素水平的变化以及辛伐他汀治疗对其水平的影响。方法:选取78例合并轻度血脂升高冠心病患者和62名健康对照者,检测2组的血清内脂素水平有无差异。78例冠心病患者再进一步随机分为常规治疗组和辛伐他汀组,每组39例,观察2组在治疗前后血清内脂素水平的变化。结果:与正常对照组相比,冠心病患者的血清内脂素水平显著升高,差异有统计学意义。血清内脂素与体重指数、收缩压、空腹血糖、胰岛素抵抗指数和三酰甘油呈正相关,而与高密度脂蛋白胆固醇呈负相关。治疗4周后,辛伐他汀组的血清内脂素水平较治疗前明显下降,差异有统计学意义;而常规治疗组的血清内脂素水平无明显变化,差异无统计学意义。结论:辛伐他汀具有降低冠心病患者血清内脂素的作用。

OBJECTIVE To investigate the serum levels of visfatin in patients with coronary artery disease and the effect of simvastatin on the serum levels of visfatin in patients with coronary artery disease.METHODS This study consisted of 78 patients with coronary artery disease and mild dyslipidemia and 62 healthy controls.The serum levels of visfatin were determined among the two groups.Then 78 patients with coronary artery disease were randomly divided into regular treatment group and simvastatin group（39 patients in each group）.The serum levels of visfatin of the two groups before and after treatment were examined.RESULTS Patients with coronary artery disease showed increased levels of serum visfatin than did normal healthy subject.The level of serum visfatin was positively associated with body mass index,systolic blood pressure,fasting blood glucose,homeostasis model assessment of insulin resistance and serum triglycerides,and negatively associated with high-density lipoprotein cholesterol.After treatment for 4 weeks,the levels of serum visfatin were significantly decreased in simvastatin group compared with those before treatment.However,No significant differences were found in the serum levels of visfatin in regular treatment group before and after treatment.CONCLUSION Simvastatin could reduce the serum levels of visfatin in patients with coronary artery disease.