摘要
目的 探讨抗病毒胶囊治疗生殖器疱疹的作用机理。方法 运用透射电镜采用负染方法 ,观察药物与单纯疱疹病毒Ⅱ型 (HSV Ⅱ )相互作用后病毒颗粒形态改变情况。结果 病毒颗粒变形 ,大小不均匀 ,包膜裸露或破损以及病毒颗粒凝集融合成块 ,结构模糊不清。结论 抗病毒胶囊在体外对HSV Ⅱ病毒颗粒的形态结构、表面成分和分散均有显著破坏作用。
Objective To study the mechanism of the antiviral capsule of traditional medicines in treating genital herpes. Methods Using the transmission electron microscope, we observed the morphologic change of the viral particles with negative staining after the interaction of the capsule and herpes simplex virusⅡ. Results The results showed that the viral particles deformed, and the sizes the particles were not uniform, the envelopes were denuded or damaged. The viral particles were fused into masses, and the structure was blurred. Conclusion The antiviral capsule has significant damaging effect on the morphosis, superficial components and dispersion degree of the viral particles.
出处
《中华微生物学和免疫学杂志》
CSCD
北大核心
2000年第4期306-308,共3页
Chinese Journal of Microbiology and Immunology
基金
国家中医药管理局科研基金!资助项目 (972 0 77)
关键词
抗病毒胶囊
单纯疱疹病毒
电镜
负染技术
Antiviral capsule
Herpes simplex virus
Electron microscope
Negative staining
