破骨细胞骨吸收功能的检测方法

The detection methods of bone resorption function of osteoclasts

破骨细胞是一种多核的,具有骨吸收功能的骨组织细胞,在骨吸收过程中起着至关重要的作用。破骨细胞骨吸收功能的异常会引发一系列的临床病症,如骨质疏松症、关节置换术后假体松动、骨硬化症和牙周病变等。破骨细胞骨吸收功能的进一步研究对于各类骨疾病的防治具有重要的意义。然而破骨细胞骨吸收功能的检测方法一直以来是制约破骨细胞研究的瓶颈之一。为此,围绕破骨细胞骨吸收功能的检测方法做一综述。

Osteoclast, which is multinucleated bone tissue cell, plays a significant role in the process of bone resorption. The dysfunction of bone resorption of osteoclast could result in a series of clinical diseases, such as osteoporosis, prosthesis loose after joint replacement, osteosclerosis and periodontal disease, etc. Further research on bone resorption function of osteoclast is essential for the prevention and cure of bone diseases. The detection method of bone resorption function of osteoclast is considered to be a limiting factor for the research on osteoclast. For this reason, this paper reviewed the detection methods of bone resorption function of osteoclast.