柴芪承气汤对肝硬化肠屏障功能障碍的影响

Influence of "chaiqichengqi decoction" on intestinal barrier dysfunction of cirrhosis patients

目的观察柴芪承气汤对肝硬化患者肠屏障功能障碍的影响。方法按随机数字表法将64例肝硬化患者分为柴芪承气汤组(治疗组)和对照组各32例。测定治疗前、治疗后3d及7d的尿乳果糖/甘露醇(LAC/MAN)比值、血浆内毒素水平和血浆二胺氧化酶(DAO)活性。结果治疗后3d和7d与治疗前相比较,两组LAC/MAN比值和内毒素水平逐渐下降,差异有统计学意义(P<0.001);治疗组较对照组下降更明显(P<0.01)。治疗组治疗前、后DAO活性无明显变化(P>0.05),对照组治疗后3d及7d升高(P<0.005);治疗后7d治疗组DAO活性明显低于对照组(P<0.05)。结论柴芪承气汤能明显改善肝硬化患者的肠屏障功能。

Objective To observe the influence of ＂chaiqichengqi decoction＇on intestinal barrier dysfunction of cirrhosis pa- tients. Methods Sixty-four cirrhosis patients were randomly divided into ＂chaiqichengqi decoction＂ treatment group（n= 32） and control group（n=32）. The ratio of urine lactulose to mannitol（LAC/MAN）,the levels of endotoxin and the plasma activity of di- amine oxidase（DAO） were detected on admission,on the day 3 and 7 after treatment. Results The ratio of cirrhosis patients was not significantly different between the two groups（P〉0.05）. From day 3 to day 7 after having been treated, the ratio of LAC/ MAN and the levels of endotoxin were decreased in the two groups and the differences were significant（P〈0.01）. The ratio of LAC/MAN and the levels of endotoxin in the treatment group were significantly decreased than those in the control group in day 3 and day 7（P〈 0.01）. The activity of DAO was increased in the control groups but didn＇t change in the treatment after day 3 and day 7. After day 7 ,the activity of DAO of the treatment group was lower than that of the control group（P〈0.05）. Conclusion The ＂chaiqichengqi decoction＂ may ameliorate the intestinal barrier dysfunction of cirrhosis patients.