前列腺素E_1对慢性肾功不全失代偿期患者肾动脉血流动力学的影响

Prostaglandin-E_1 delays deterioration of renal function

目的 了解前列腺素 E1 (PGE1 )对慢性肾功不全(CRF)失代偿期患者肾动脉血流动力学的影响 .方法 利用彩色多普勒观察 5 0例 CRF失代偿期患者经 PGE1 治疗前、后的肾动脉血流动力学的变化 .结果 CRF失代偿期患者肾动脉血流动力学的各项参数 ,特别是肾动脉内径 (D)、时间速度积分 (VTI)、阻力指数 (RI)变化显著 (P<0 .0 1) ;PGE1 治疗后 ,其各项参数均有明显的变化 (P<0 .0 5 ) ;同时 BU N,Cr水平由治疗前的 (15 .14± 5 .37) mmol· L- 1 ,(193.6 1±5 1.35 )μmol· L- 1 降至 (7.89± 6 .0 4) mmol· L- 1 ,(98.99±35 .17)μmol· L- 1 ,尿量由 (948.3± 12 7.7) m L· d- 1 增至(12 41.6± 372 .9) m L· d- 1 ,均有明显的改善 (P<0 .0 5 ) .结论 CRF失代偿期时多伴有凝血、纤溶障碍所导致的肾动脉血流动力学变化 ,用 PGE1

AIM To observe the effect of prostaglandin-E 1 (PGE 1) on the kinetic of renal arterial blood flow in chronic renal failure (CRF). METHODS The renal color Dopplorultruresound was used to examine renal arterial blood flow before and after treatment with PGE 1 in 50 CRF patients and 48 controls. RESULTS The parameters of CRF patients' kinetic of renal arterial blood flow, including the diameter of renal arterial, velocity time integral (VTI) and drag index (RI) significantly changed; after treatment with PGE 1 the parameter mentioned above changed as well ( P <0.05); the parameter of renal function (BUN, Cr, urine) also simultaneously improved ( P <0.05). CONCLUSION The kinetic change of renal arterial blood flow in CRF patients results from obstacle of companioning cruor and fine dissolve. The application of PGE 1 in treatment of renal failure is beneficial to delay deterioration of renal function.